2. Articole
Permanent URI for this collectionhttps://msuir.usm.md/handle/123456789/13397
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Item COMPLETE ASSIGNMENTS OF THE 1H, 13C AND 15N SPECTRA FOR (±)-MONASTROL BY 1D AND 2D HR NMR TECHNIQUES(CEP USM, 2024) Gorincioi, Elena; Ciobanu, NataliaThe current communication reports on the use of Nuclear Magnetic Resonance (NMR) Spectroscopy for full NMR characterization of monastrol, a well-explored synthetic molecule that has demonstrated significant biological effects of suppressing the motility of the mitotic motor protein kinesin Eg5. Our work has been aimed at complete NMR characterization of the title compound, since no available data in the literature were found, presenting the full assignment of 1H, 13C and 15N nuclei in its structure. The combination of 1D and 2D HETCOR 1H-13C and 1H-15N NMR experiments spectra were employed to provide an unambiguous set of assignments. NMR characteristics for the nitrogen nuclei of N,N’-disubstituted thiourea fragment are presented for the first time.Item NOI OPORTUNITATI IN SINTEZA MONASTROL(CEP USM, 2024) Ciobanu, NataliaVarious ratios (from 2:1 to 1 :3) was achieved. Physical state and established catalytic activity of monastrol synthesis. It showed a wide range of pharmacological activities. Recently, there has been a great deal of interest in the importance of dihydropyrimidines. Dihydropyrimidines play important roles in various biological processes in different body structures carrying important information. Currently, the most effective method to synthesize dihydropyrimidines remains the well-studied multicomponent Biginelli reaction. The Biginelli reaction is commonly used to directly produce monastrol and its derivatives and has many advantages over traditional synthetic methods.