Browsing by Author "Roșca, Nicolae"

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    ADVANTAGES OF CRYOCONSERVATION OF SPERM IN REPRODUCTIVE BIOTECHNOLOGY
    (CEP USM, 2022-09-29) Roșca, Nicolae; Balan, Ion; Balacci, Sergiu; Buzan, Vladimir; Crețu, Roman; Moroz, Mihail; Osipciuc, Galina; Bacu, Gheorghe
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    APORTURILE MONETARE ŞI NEMONETARE LA FORMAREA CAPITALULUI SOCIAL AL SOCIETĂŢII COMERCIALE
    (2011) Roșca, Nicolae
    The social contribution is a patrimonial contribution of the the founder to the social capital formation, and the capital is the original heritage which helps the company to start it’s way. There are legal settlements about the assets, their valuation, terms of transmission, the rights submitted, the consequences of delay. Considering the general terminology of the legal settlements, the author makes analysis, gives interpretations, makes suggestions for the exactly understanding of the legal texts and their proper application.
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    INFLUIENȚA EXTRACTULUI DE POLIFENOLI DIN NUCILE VERZI ASUPRA METABOLISMULUI GLUTATIONULUI DIN SERIUL SANGUIN AL COCOȘILOR
    (CEP USM, 2024) Roșca, Nicolae; Balan, Ion; Buzan, Vladimir; Balacci, Sergiu; Furdui, Vlada; Mereută, Ion; Osipciuc, Galina; Crețu, Roman; Bacu, Gheorghii
    In this paper, the influence of polyphenol extract from green walnuts on glutathione metabo lism in the blood serum of breeding roosters was studied. To achieve this purpose, hydroalcoholic extract from green walnuts was used, with a total antioxidant activity of 548,37 mg gallic acid equivalent/100 gr. For the study were used two batches of roosters, of five animals in each batch, experimental and control. As a result of the research on the influence of metabolism, changes were obtained in the content of SH-groups, G-TP, G-S-T, as well as amino acids, which are part of the glutathione composition and which were studied in different biological fluids and repro ductive cells. The basic mechanism of the central role of thiol-mediated redox control in cellular metabolism is the ability of thiol groups to reversibly change their redox state with subsequent changes in the conformational, catalytic or regulatory functions of the protein.
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    MECANISME JURIDICE DE COMBATERE A ACORDURILOR ANTICONCURENȚIALE ȘI PROTECȚIE A CONCURENȚEI ÎN LEGISLAȚIA REPUBLICII MOLDOVA
    (2021) Creciun, Ilie; Roșca, Nicolae
    Scopul lucrării: analiza esenței mecanismelor juridice de combatere a acordurilor anticoncurențiale și protecție a concurenței în legislația Republicii Moldova, evidențierea și caracterizarea componentelor fiecărui mecanism, precum și determinarea particularităților aplicării acestor mecanisme juridice.
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    Morfofuncționalitatea mitocondrială în evoluția spermatogenezei la mamifere
    (Editura USM, 2024) Balan, Ion; Surai, Peter; Marin, Paula Monica; Balacci, Sergiu; Roșca, Nicolae; Buzan, Vladimir; Petcu, Igor; Mereuță, Ion; Osipciuc, Galina; Popa, Valerian; Vîhrist, Ecaterina
    In spermatogenesis, mitochondria are particularly important for the development and maintenance of germ cells and the production of healthy gametes. Deficiencies in these processes lead to mitochondrial dysfunction and abnormal spermatogenesis. The classical roles of mitochondria in energy production, metabolism and apoptosis have been well defined, but they also have various other functions. Mitochondria are also involved in testosterone production, regulating proton secretion in the lumen to maintain an acidic state in the epididymis, and condensing sperm DNA. In the available literature on sperm mitochondria, it is increasingly recognized that the morphology and functional status of mitochondria has a significant impact on sperm characteristics. Although mitochondria are recognized as essential for sperm, their exact pathophysiological role and functioning are complex. Understanding and managing mitochondrial quality control could be a valuable approach for developing new strategies in the physiological evolution of spermatogenesis.
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    NECESITATEA SPECIALIZĂRII INSTANŢELOR COMPETENTE ÎN MATERIE DE INSOLVABILTIATE
    (2014) Roșca, Nicolae; Ilana, Ana
    Specializarea judecătorilor este privită ca un imperativ al timpului, deoarece justiţiabilii îşi doresc ca litigiile lor să fie soluţionate cu celeritate şi profesionalism pentru a limita la maximum riscul de erori judiciare. Analiza legislaţiei din România şi din Republica Moldova demonstrează că dispoziţiile legale cu privire la specializarea instanţelor și/sau a judecătorilor în domeniul insolvabilităţii lasă de dorit. Deşi o specializare îngustă a judecătorilor ar impune cheltuieli mari, totuşi ajungem la concluzia că o reducere a numărului categoriilor de dosare, aflate în procedura aceluiaşi judecător, ori atribuirea doar a unor categorii de dosare ar contribui la îmbunătăţirea actului de justiţie în domeniul insolvabilităţii.
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    Proprietățile celulelor stem spermatogoniale în mediul nișelor fiziologice și metabolice testiculare
    (Editura USM, 2024) Balan, Ion; Gavojdian, Dinu; Budevici, Alexandr; Roșca, Nicolae; Buzan, Vladimir; Balacci, Sergiu; Osipciuc, Galina; Furdui, Vlada; Harea, Vasile; Cretu, Roman; Bacu, Gheorghe; Țurcanu, Parascovia; Temciuc, Vlad; Filippov, Artiom
    Spermatogenesis is a continuous process, maintained by the self-renewal and differentiation of spermatogonial stem cells (SSC), which arise from undifferentiated precursors (gonocytes) in the physiological conditions of the testicular cell niche. SSC serve as the foundation for the physiology of continuous spermatogenesis, they have the ability to self-renew by differentiation to produce spermatozoa suitable for fertilization, therefore the knowledge of the regulatory processes of SSC is of great importance for understanding the fundamental molecular mechanisms of the function of these cells in spermatogenesis. By strict physiological regulation, spermatogonial transitions occur with a complete non-exploitation of equivalent changes in metabolism, a conserved overregulation of mitochondrial function, biogenesis and oxidative phosphorylation in spermatogony differentiation, as well as the relationship between metabolism and the external microenvironment. In the present paper we have tried to review the current state of research in CSS physiology and biology, as well as their molecular regulation, in the physiological and metabolic niches, necessary for fundamental investigations and possible practical applications. Elucidation of the exact mechanisms and characteristics of testicular maturation events and gonocyte transition to SSC by activation of CSS-specific pathways or early embryonic establishment of transcriptional profiling of neonatal and prepubertal spermatogonia will contribute to new achievements of biological, physiological and metabolic aspects of SSC. Increased knowledge regarding the biology, physiology and metabolism of SSC will improve our understanding of the possibilities of applying SSC tools and manipulations in the evolution of spermatogenesis mechanisms.
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    THE ROLE AND IMPORTANCE OF REPRODUCTIVE BIOTECHNOLOGIES IN ANIMAL BIODIVERSITY
    (CEP USM, 2022-09-29) Balan, Ion; Roșca, Nicolae; Buzan, Vladimir; Balacci, Sergiu; Cazacova, Iulia; Mereuța, Ion; Crețu, Roman; Bacu, Gheorghe
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    STIMULAREA SPERMATOGENEZEI LA COCOŞII REPRODUCĂTORI
    (2012-09-27) Boronciuc, Gheorghe; Gulea, Aurelian; Țurcanu, Ștefan; Roșca, Nicolae; Balan, Ion; Varmari, Nina; Bârcă, Maria; Didilica, Ina
    The purpose of research was a development of a method of stimulation spermatogenesis at cocks which will provide quantitative and qualitative increase in indicators of sperm. By means of physiological methods was established that the drug LAZ promotes increase spermatogenesis at cocks. It was used by an oral way in a dose of 1 ml on an individual of cock, within 5 weeks. An active component of a coordinative drug with stimulating property is easily assimilated.