2. Articole

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    Model-assisted Adaptive Designs for Dose-ranging Clinical Trials [Articol]
    (2024) Dragalin, Vladimir
    The overall goal of dose-ranging studies is to establish the existence, nature, and extent of dose effect. Recently, a great effort has been made to investigate and develop designs and methods for efficient learning about dose response and more accurate and faster decision making on dose. The focus is on adaptive modelassisted optimal designs of experiments modeling safety, efficacy, or both efficacy and safety endpoints. The proposed dose allocation rules are based on a combination of D- and c-optimality criteria in optimal design of experiments.