Browsing by Author "Tsapkov Victor"

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    Synthesis and antitumor activity of copper, nickel and cobalt coordination compounds with 1-(2-hydroxyphenyl)ethanone n(4)-allyl-3-thiosemicarbazone [Articol]
    (CEP USM, 2015) Graur, Vasilii; Savcin Serghei; Tsapkov Victor; Gulea, Aurelian
    The paper presents the synthesis of the ligand 1-(2-hydroxyphenyl)ethanone N(4)-allyl-3-thiosemicarbazone (H2 L) and six coordination compounds of copper, nickel and cobalt with this ligand. The structure of thiosemicarbazone H2 L was studied using 1 H and 13 С NMR spectroscopy. The synthesized coordination compounds were studied using elemental analysis, gravimetric analysis of water content, molar conductivity, and magnetochemistry. For H2 L the antitumor activity towards human leukemia HL-60 cells and cervical cancer HeLa cells was determined. It was established that the substitution of hydrogen atom with methyl group in the azomethinic fragment leads to the growth of antitumor activity.