Browsing by Author "Tsapkov, V. I."

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Coordination compounds of cobalt, nickel, copper, and zinc with n1 ,n2 -bis(pyridin-2-ylmethylidene)benzene-1,2-diamine and its derivatives [Articol]
(Pleiades Publishing Ltd., 2014) Pahonțu, Elena; Gulea, Aurelian; Poirier, D.; Tsapkov, V. I.
о-Phenylenediamine reacts with 2-formyl-, 2-acetyl-, or 2-benzoylpyridine in ethanol in the presence of cobalt, nickel, copper, or zinc chlorides to form monomeric complexes ML1−3Сl2·nH2O {M = Co,Ni, Cu, Zn; L1 = N1,N2 -bis(pyridin-2-ymethylidene)benzene-1,2-diamine, L2 = N1,N2-bis(pyridin-2-ylethylidene)benzene-1,2-diamine,L3 = N1,N2-bis[phenyl(pyridin-2-yl)methylidene]benzene-1,2-diamine; n = 0–3}.The condensation products (L1−L3) act in the complexes as tetradentate N,N,N,N-ligands. Thermolysis of thecomplexes occurs in two stages: dehydration (70–95°С) and complete degradation (320–450°С). At concentrations of 10–5–10–7 M, the complexes inhibit in vitro growth and proliferation of HL-60 human promyelocytic leukemia cells.
Crystal structure of [2-(2-hydroxybenzilydene)- hydrazinecarboxoamidato(1-)][2-(2-hydroxybenzilydene)- hydrazinecarboxoamidato(2-)]chromium monohydrate [Articol]
(MAIK Nauka/Interperiodica, 2013) Chumakov, Yurie; Tsapkov, V. I.; Petrenko, P. A.; Gulea, Aurelian; Palomares-Sànchez, S. A.
The crystal structure of [2-(2-hydroxybenz lydene)hydrazinecarboxoamidato(1-)][2-(2-hydroxy- benzilydene)hydrazinecarboxoamidato(2-)]chromium monohydrate [Cr(HL)(L)]⋅H2O (I), where H2L is salicylaldehyde semicarbazone, is determined. In I the central chromium atom is octahedrally surrounded by two ligand anions in the mer position and coordinated azomethine nitrogen atoms, phenol and carbamide oxygen atoms. In both ligands phenol groups are deprotonated; in one of them the imine group is also deprotonated. In the crystal, complexes of the compound studied are hydrogen bonded into layers along the [100] direction, with π–π stacking being observed between the phenyl rings inside the layer along with the X–Н⋯Cg (π ring) interaction.
Crystal structure of nitrate tris(4-allylthiosemicarbazide)-chromium(III) hydrate [Articol]
(Springer Verlag, 2016) Chumakov, Yu. M; Petrenko, P. A.; Graur, V. O.; Tsapkov, V. I.; Gulea, A. P.
The crystal structure of nitrate tris(4-allylthiosemicarbazide)chromium(III) hydrate [CrL3](NO3)3(H2O)1.05 (I), where L is 4-allylthiosemicarbazide, is determined. The asymmetric unit of the cell of the crystal structure of I contains a complex of a chromium ion with three bidentate coordinated molecules L. The outer coordination sphere of the central atom contains a disordered water molecule and three nitrate ions. The coordination polyhedron of the chromium atom in complex I is an octahedron. In the crystal, the complexes of the compound under study are joined with each other by the outer-sphere nitrato groups into a three-dimensional branched net of hydrogen bonds.
Crystal Structures of 5-Bromo-2-Hydroxybenzaldehyde, 2-Hydroxy-3-Methoxybenzaldehyde, and 2-Hydroxynaphthalene- 1-Carbaldehyde 4-(2-pyridyl) Thiosemicarbazones [Articol]
(MAIK Nauka/Interperiodica, 2014) Chumakov, Yu. M.; Petrenko, P. A.; Codita, T. B.; Tsapkov, V. I.; Poirier, D.; Gulea, Aurelian
5-Bromo-2-hydroxybenzaldehyde,2-hydroxy3-ethoxybenzaldehyde,and 2-hydroxynaphthalene-1-carbaldehyde 4-(2-pyridyl) thiosemicarbazones (I–III, respectively) were synthesized and theircrystal structures were determined by X-ray diffraction. All these molecules are almost planar. The presenceof bulky substituents at the terminal nitrogen atoms of these molecules does not lead to changes in the conformation of the thiosemicarbazide moiety. Depending on the nature of substituents in the phenol rings, thecrystals are composed of either centrosymmetric dimers (I) or infinite chains (II and III. In the concentration range of 10–5–10–7 mol/L, thiosemicarbazones I–III selectively inhibit the growth of human myeloidleukemia HL60 cells.
Crystal structures of [N′-(2-oxidobenzylidene)-N-(prop-2-en-1-yl)-carbamohydrazonothioato (2-)](1, 10-phenanthroline) copper and [N′-(2-oxidobenzylidene)-N-(prop-2-en-1-yl)-carbamohydrazonothioato (2-)](2, 2′-bipyridine) copper hemihydrates [Articol]
(2022) Chumakov, Yu. M.; Graur, V. O.; Ulchina, Ya. I.; Smaglii, V. A.; Gulea, A. P.; Garbuz, O. S.; Tsapkov, V. I.
The crystal structures and biological properties of [N′-(2-oxidobenzylidene)-N-(prop-2-en-1-yl)-carbamohydrazonothioato(2-)](1,10-phenanthroline)copper hemihydrate [Cu(1,10-Phen)(L)]·0.5H2O (I) and [N′-(2-oxidobenzylidene)-N-(prop-2-en-1-yl)-carbamohydrazonothioato(2-)](2,2′-bipyridine)copper hemihydrate [Cu(2,2′-BPy)(L)]·0.5H2O (II), where Н2L is 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide, are determined. The asymmetric unit of the unit cell in the crystal structures of I and II contains a copper complex with bidentate amine and a ligand coordinated by the azomethine nitrogen atom, the deprotonated phenolic oxygen atom, and the sulfur atom in the thiol form. The coordination polyhedron of the copper atom in compounds I and II is a distorted tetragonal pyramid. Obtained coordination compounds I and II exhibit antimicrobial and antifungal activities and have minimum inhibitory concentration and bactericidal concentration values in a range of 1.5-500 µg/mL. The study of the antioxidant activity shows that compounds I and II are less active than uncoordinated thiosemicarbazone H2L, but more active than trolox used in medical practice.
Synthesis and antimicrobial activity of coordination compounds of copper with substituted salicylaldehyde thiosemicarbazones [Articol]
(Springer, 2005) Prisakar, V. I.; Tsapkov, V. I.; Buracheeva, S.A.; Byrke, M.S.; Gulya, A. P.
New coordination compounds of copper(II) with thiosemicarbazones of 5-chloro-, 5-bromo-, 5-nitro-, 5-methyl-, 3,5-dichloro-, and 3,5-dibromo-substituted salicylaldehyde have been synthesized and tested with respect to eight strains of staphyloccoccus, streptococcus, and colon bacillus. These compounds exhibit high antimicrobial activity. The composition and structure of the synthesized complexes have been studied by means of elemental analysis and by magnetochemical, IR, and thermogravimetric techniques. The antimicrobial activity of the obtained coordination compounds depends both on the nature of substituents in the benzene ring of salicylaldehyde and on the nature of acid ligands. The maximum antimicrobial activity was observed for copper(II) complexes with thiosemicarbazone of 3,5-dibromsalicyladehyde.
Synthesis, Structure, and Biological Activity of Copper(II), Nickel(II), Cobalt(III), and Iron(III) Coordination Compounds with 2-{2-[(Prop-2-en-1-yl) carbamothioyl] hydrazinylidene} propanoic Acid [Articol]
(2020) Gulea, А. P.; Graur, V. О.; Diuricia, E. C.; Ulchina, Ia. I.; Bourosh, P. N.; Balanc, G. G.; Burduniuc, O. S.; Tsapkov, V. I.; Rudic, V. F.
2-Oxopropanoic acid reacts in ethanol with N-(prop-2-en-1-yl)hydrazinecarbothioamide in a 1 : 1 mole ratio to form thiosemicarbazone H2L. Coordination compounds Cu(HL)X [X = Cl–, Br–, NO 3 –], Cu(H 2O)(L), Ni(HL)2, Co(HL)2X [X = Cl–, Br–], and Fe(HL)2X [X = NO3 – , Br–] are formed in the reactions of H2L with copper(II), nickel(II), cobalt(II), and iron(III) salts. The reactions of Cu(H2O)(L) with imidazole (Im) and 3,4-dimethylpyridine (3,4-Lut) result in mixed-ligand complexes Cu(A)(L) [A = Im, 3,4-Lut]. The structures of two copper complexes were determined by single crystal X-ray diffraction analysis. The synthesized complexes exhibit selective antimi- crobial and antifungal activity in the concentration range of 15.62–1000 μg/mL. The introduction of amines into the inner sphere of copper complexes leads to an increase in the antimicrobial activity.
Synthesis, Structure, and Biological Activity of Mixed-Ligand Amine-Containing Copper(II) Coordination Compounds with 2-(2- Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide [Articol]
(2021) Gulea, А. P.; Graur, V. О.; Ulchina, Ia. I.; Bourosh, P. N.; Smagliic, V. A.; Garbuz, O. S.; Tsapkov, V. I.
Сopper(II) nitrate reacts in ethanol with 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbo- thioamide H2L in an 1 : 1 molar ratio to form the coordination compound Cu(HL)NO3·H 2O. The introduction of amines [imidazole (Im), 3,5-dibromopyridine (3,5-Br2Py), and 4-methylpyridine (4-Pic)] into the reaction mixture in a molar ratio 1 : 1 : 2 leads to the formation of CuA(HL)NO3·nH 2O [A = Im, 3,5-Br 2Py, 4-Pic; n = 0, 3] com- plexes. The structure of the obtained compounds was determined by X-ray structural analysis. The synthesized complexes exhibit antimicrobial, antifungal, antioxidant, and anticancer activities.