Browsing by Author "Tsapcov, Victor"

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    SYNTHESIS AND BIOLOGICAL ACTIVITY OF COPPER(II) COORDINATION COMPO UNDS WITH 2 - HYDROXY - 1 - NAPHTHALDEHYDE N (4) - ALLYL - 3 - THIOSEMICARBAZONE
    (CEP USM, 2020) Ulchina, Ianina; Tsapcov, Victor; Graur, Vasilii; Gulea, Aurelian
    The paper presents the synthesis of the 2-hydroxy-1-naphthaldehyde N(4)-allyl-3-thiosemicarbazone (H2L) and seven coordinationcompounds of copper with this ligand and heteroaromatic amines. The new obtained compounds were investigated by elemental analysis, IR spectroscopy and molar electric conductibility. For the ynthesized compounds the antibacterial and antifungal activities in vitro were studied on a series of standard strains, such as Staphylococcus aureus (ATCC 25923),Bacillus cereus (ATCC 11778),Bacillus subtilis (ATCC 6633), Candida albicans (ATCC 10231) andCandida krusei (ATCC 6258). The nature of heteroaromatic amines influences the activity of the oordination compounds that decreases in the following way: 3,4-Lut > 1,10-Phen > 2,2’-Bpy > Py > 4-Pic > 3 -Pic. Almost all stuied substancesmanifest high antioxidant activity towards ABT S•+that exceeds the activity of Trolox which is used as standard antioxidant.
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    SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COPPER(II), NICKEL(II), COBALT(III) AND IRON(III) COORDINATION COMPOUNDS WITH 2-HYDROXY-3-METHOXYBENZALDEHYDE N(4)-ALLYL-S-METHYLISOTHIOSEMICARBAZONE
    (CEP USM, 2018) Usataia, Irina; Graur, Vasilii; Tsapcov, Victor; Gulea, Aurelian
    The paper presents the synthesis of the 2-hydroxy-3-methoxybenzaldehyde N(4)-allyl-S-methylisothiosemicarbazone (HL) and seven coordination compounds of copper, nickel, cobalt and iron with this ligand. The new obtained compounds were studied using IR, 1H and 13C NMR spectroscopy, elemental analysis, molar electric conductibility and magnetic susceptibility. The in vitro antiproliferative activity of the HL and synthesized coordination compounds was screened on HeLa cancer cells and normal MDCK cells. The isothiosemicarbazone HL shows better anticancer activity towards HeLa cancer cells than doxorubicin that is used in medical practice and it also practically does not affect the growth and proliferation of normal cells. Moreover, it manifests high antioxidant activity towards ABTS•+ radical cation that exceeds the activity of trolox.