Browsing by Author "Tolstenco, Dorina"

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    COMPATIBILITATEA UNOR PLANTE MEDICINALE CU PROPRIETĂȚI ANTICANCERIGENE CU REPREZENTANȚI AI FLOREI MICROBIENE INTESTINALE
    (CEP USM, 2023-02-13) Leorda, Ana; Şeptiţchi, Vladimir; Tolstenco, Dorina
    The present study was designed to evaluate the antimicrobial efficacy to Chelidonium majus, Viscum album, Artemisia absinthium, Xanthium spinosum and Acorus calamus against microbial strain E. coli, as well as their compatibility with representatives of the normal microbial flora.
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    FACTORII ALIMENTARI SANO- ȘI DISSANOGENI, COMUNI PENTRU MICROBIOCENOZA INTESTINALĂ ȘI SISTEMUL REPRODUCĂTOR MASCULIN
    (Editura USM, 2024) Leorda, Ana; Furdui, Vlada; Tolstenco, Dorina
    Diet composition is the most important extrinsic factor influencing individual differences in intestinal microbiota, and nutritional factors play a key role in determining reproductive health and can positively or negatively influence human fertility. Thus, extrinsic factors with a sanogenic character are of particular importance, which on the one hand have a positive impact on MI, and this in turn on the reproductive system, and on the other hand directly influence this system. The healthy and unhealthy aspects of the food ration with a common impact on the intestinal microbiocenosis and the reproductive system have been identified, since understanding the factors that contribute to affecting MI and decreasing male fertility is crucial for minimizing their impact. The role of intermittent fasting in maintaining the health of these two systems was also elucidated, as well as the effects of alcohol depending on the dose used.
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    IMPACTUL SANO- ȘI DISSANOGEN AL DIETEI ASUPRA HOMEOSTAZIEI MICROBIOTEI INTESTINALE ȘI RELAȚIA ACESTEIA CU METABOLISMUL AMINOACIZILOR
    (CEP USM, 2024) Leorda, Ana; Garaeva, Svetlana; Tolstenco, Dorina
    Despite extensive scientific evidence supporting the relationship between dietary factors and gut microbiota composition and function, the underlying mechanisms and their potential impact are far from clear. Thus, the paper aim is to elucidate the components of the diet with a sanogenic and dissanogenic impact on the intestinal microbiota and its relationship with amino acid metabolism. Food intake has an indisputable impact on the development of the intestinal microbiota. The individual intestinal microbiota, while remaining relatively stable in a healthy organism, can vary qualitatively and quantitatively under of internal and external factors influence. The diet protein component targeted modification can regulate the functioning of microbial populations, which determines the sanogenicity of the body’s homeostasis.
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    MODIFICĂRILE CANTITATIVE ȘI CALITATIVE ALE MICROBIOTEI INTESTINALE CA PREDICTOR PRECOCE AL CANCERULUI COLORECTAL
    (CEP USM, 2024) Leorda, Ana; Șeptițchi, Vladimir; Tolstenco, Dorina
    As a pressing global health problem, colorectal cancer (CRC) requires effective therapeutic strategies, and the underlying mechanisms remain an essential subject of investigation in this field. The problem of identifying some predictive markers of the probability of the appearance of this type of malignant neoplasms is quite current. Disturbance of the normal community of intes tinal bacteria represents an important problem in the development of CRC, thus new predictive markers of the probability of the appearance of this type of malignant neoplasms can be identi fied in changes in the qualitative and quantitative composition of the intestinal microbiota (MI). The subsequent development of preparations based on previously identified indigenous medicinal plants, which on the one hand have an anti-cancer effect, and on the other hand possess prebiotic properties, stimulate the multiplication of normal intestinal microbial flora. Targeted formation and maintenance of normal intestinal microbiota will be the basis for the development of new strategies in the prevention and treatment of CRC.
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    ROLUL PLANTELOR MEDICINALE ONCOPROTECTOARE ȘI AL REMEDIILOR PE BAZA LOR ÎN TERAPII ANTICANCER
    (CEP USM, 2022) Leorda, Ana; Tolstenco, Dorina
    În articol au fost elucidate unele mecanisme de acțiune relevante ale plantelor medicinale oncoprotectoare și ale re- mediilor pe baza lor în terapii complementare anticancer. Având în vedere efectele secundare, toxicitatea și costurile mari, inerente terapiilor anticancer tradiționale, rămâne a fi actuală identificarea de noi compuși din surse naturale, inclusiv plante medicinale sigure și eficiente împotriva chimiorezistenței și împotriva cancerului, ceea ce oferă perspective pro- mițătoare în tratarea acestei maladii. Apariția și perfecționarea noilor tehnologii, cum ar fi tehnicile genetice pentru pro- ducerea de metaboliți secundari ai plantelor, sinteza combinatorică, precum și identificarea compușilor derivați în mod natural din plantele medicinale oncoprotectoare și proprietățile acestora le fac ținte pentru potențiale tratamente anticancer. În același timp, din cauza utilizării crescute a produselor pe bază de plante de către pacienții cu cancer, trebuie acordată o mai mare atenție utilizării lor în combinație cu agenții anticancer.