Browsing by Author "Tagadiuc, O.C."

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    ANTIPROLIFERATIVE AND ANTIOXIDANT ACTIVITY OF NITRATO-[4-(3,4-DIMETHYLPHENYL)-2-(2-OXO-3-METHOXYBENZYLIDENE) HYDRAZINECARBOTHIOAMIDO]COPPER
    (Marina Sokolova Publishings, 2018) Gulea, A.P.; Gudumac, V.S.; Garbuz, O.S.; Cebotari, D.Y.; Spinu, I.C.; Pirvu, O.I.; Sardari, V.V.; Tagadiuc, O.C.; Gostev, I.V.; Spinu, C.I.; Scoferta, P.G.
    In the present study, the ability of nitrato-[4-(3,4-dimethylphenyl)-2-(2-oxo-3-methoxybenzylidene) hydrazinecarbothioamido] copper (CDI-14) – new coordination compound of the thiosemicarbazone class of biometals to induce the inhibition of proliferation in HeLa and BxPC-3 cancer cell lines was investigated. Its cytotoxicity against MDCK normal cell line was also evaluated. The viability of each cell line was determined by the Resazurin test. Doxorubicin was used as a positive control. The antioxidant activity was evaluated by ABTS assay and compared with those of the standards, trolox and rutin.Obtained results showed that compound CDI-14 has a good antioxidant potential and high antiproliferative activity against HeLa and BxPC-3 cancer cell lines. It was also observed that the tested compound did not affect the cytotoxic activity of MDCK normal cell line, which indicates its selective toxicity and the possibility of its use as an anticancer agent.
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    IN VITRO ANTIPROLIFERATIVE POTENTIAL AND ANTIOXIDANT CAPACITY OF NEW COORDINATION COMPOUNDS
    (Marina Sokolova Publishings, 2017) Garbuz, O.S.; Graur, V.O.; Tagadiuc, O.C.; Andronache, L. M.; Sradari, V.V.; Gulea, A.P.; Gudumac, V.S.
    In the present study the ability of coordination compounds TIA - 90, TIA - 91 and TIA - 93 to induce the inhibition of proliferation in the epithelial ce lls of pancreatic carcinoma of the BxPc - 3 line were investigated. Their cytotoxicity against normal kidney epithelial cells of Madin Darby dog's MDCK line was also evaluated. The viability of cancer cells was determined by the Alamar Blue test using the re dox indicator of resazurin. To identify the antioxidant properties of TIA - 90, TIA - 91 and TIA - 93 anticancer agents, we used a relatively simple but reliable ABTS method. Obtained results showed that the compounds TIA - 90 and TIA - 93 have greet antiproliferati ve and antioxidant potentials. The cytotoxic activity of these compounds against normal cells of the MDCK line is lower than that on tumor cells, which indicates the prospect of their use as antitumor agents. However, additional studies are need to evaluate the mechanisms of action of these compounds, as well as their possible adverse effects in other bioassay systems and animal models