Browsing by Author "Stratulat, Elena"

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Complexarea ionilor de nichel (II) cu 4-hidroxi-3-((2-(fenilcarbamotioil) hidrazono) metil) benzensulfonatul de sodiu în soluţii apoase [Articol]
(CEP USM, 2022-11-10) Sîrbu, Angela; Palamarciuc, Oleg; Stratulat, Elena
Complexarea tiosemicarbazonei aldehidei 5-sulfosalicilice sub formă de sare de sodiu cu ionii de nichel(II) în soluţii apoase [Articol]
(CEP USM, 2022) Sîrbu, Angela; Palamarciuc, Oleg; Stratulat, Elena
Interacțiunea ionilor de Ni(II) cu tiosemicarbazona aldehidei 5-sulfosalicilice în formă de sare de sodiu (NaH2L) a fost studiată prin metoda spectrofotometrică UV-Vis. Raportul molar de combinare metal:ligand a fost determinat folosind două metode: metoda raporturilor molare și metoda variațiilor continue. NaH2L formează cu ioni de nichel(II) un complex de culoare galbenă cu raportul de combinare metal:ligand = 1:1, la λ max = 374 nm și rămâne stabil în domeniul de pH 5,80 – 6,60. Dependența absorbanței complexului studiat de concentrația ionilor de nichel(II) este o dependență liniară în domeniul de concentrații 6,0∙10-5 M – 1,1∙10-4 M. Constanta de stabilitate a complexului determinată în formă logaritmică corespunde cu 5,74.
Formarea şi stabilitatea compuşilor coordinativi ai cobaltului cu chalcogensemicarbazonele 8-formilchinolinei în soluţii [Articol]
(CEP USM, 2022-11-10) Stratulat, Elena; Palamarciuc, Oleg
Investigation of the cytotoxic potential of methyl imidazole-derived thiosemicarbazones and their copper(ii) complexes with dichloroacetate as a co-ligand† [Articol]
(Royal Society of Chemistry, 2018) Palamarciuc, Oleg; Sîrbu, Angela; Stratulat, Elena
A series of six imidazole-derived thiosemicarbazones (HL1–HL6) and their copper(II) complexes (1–6)were synthesised and characterised by analytical, spectroscopic, electrochemical and single crystal X-raydiffraction techniques. In addition, solution studies and the results of antiproliferative activity in human cancer cell lines with some insights into the mechanism of cancer cell death are also reported. In particular, the substitution of one hydrogen at the terminal N-atomof the thiosemicarbazide moiety by a phenyl group resulted in slightly enhanced antiproliferative activity.HL3andHL6showed lower IC50values comparedtoHL1andHL4in MDA-MB-453 and LS174 cancer cell lines. The copper(II) complexes3and6exhibit a2.4- and 4.7-fold increase of activity compared to parent proligands in MDA-MB-453 cancer cell line,respectively. The complex formation of the proligands with copper(II) increased their antiproliferative activity in all investigated cell lines. The cell cycle perturbations, apoptotic potential and the analysis of morphological changes in the A549 cell line induced by3and6revealed cytostatic rather than cytotoxic effect
Rational design of single molecule magnets with thiosemicarbazone ligands [Articol]
(Academia de Ştiinţe a Moldovei, 2015) Palamarciuc, Oleg; Secu, Mihail; Palamarciuc, Tatiana; Stratulat, Elena; Shova, Sergiu; Clerac, Rodolphe
Structure and antimicrobial activity of the copper(II) complex with 8-formylquinoline 4-ethyl-thiosemicarbazone [Articol]
(Academia de Ştiinţe a Moldovei, 2012) Bourosh, Pavlina; Stratulat, Elena; Corja, Ion; Dizdari, Anna; Gdaniec, Maria; Revenco, Mihail; Prisakari, Viorel I.
Supramolecular assemblies of CU(II) systems based on thiosemicarbazone ligand [Articol]
(Academia de Ştiinţe a Moldovei, 2015) Palamarciuc, Tatiana; Stratulat, Elena; Shova, Sergiu; Pui, Aurel; Palamarciuc, Oleg
Synthesis, structure and biological properties of copper(II) coordination compounds with quinoline 4-substituted thiosemicarbazone [Articol]
(Academia de Ştiinţe a Moldovei, 2015) Stratulat, Elena; Bourosh, Pavlina; Corja, Ion