Browsing by Author "Poirier, Donald"

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AROMATIC ISOTHIOCYANATOPROPENONES AND THIOUREA DERIVATIVES. SYNTHESIS AND BIOLOGICAL PROPERTIES
(2014) Barba, Nicanor; Gulea, Aurelian; Popușoi, Ana; Lozan-Tîrșu, Carolina; Poirier, Donald
În prezenta lucrare se descriu metode de sinteză a unor propenone aromatice cu grupe tioamidice sau izotiocian şi caracteristica lor biologică in vitro. Prin condensarea în cataliză acidă sau bazică a 4-(dimetilamino)benzaldehidei 4-Hidroxi-3-metoxibenzaldehidei şi furan-2-carbaldehidei cu 3-(4-acetilfenil)-1,1dimetiltioureea au fost obţinute propenone aromatice cu grupări –NHCSN(CH3)2, care la tratare termică sau în prezenţă de agenţi cu caracter acid (HCl, H2SO4, (CH3CO)2O, CH3COCl) elimină dimetilamină, transformîndu-se în izotiocianato -propenon cu randamentul de 54-92 %. La tratarea izotiocianatopropenonelor cu amine primare au fost obţinuti derivaţi cu grupări tioamidice-NHCSNH. Structura compuşilor noi obţinuţi cu conţinut de sulf a fost confirmată prin analiză elementală şi spectrală IR, 1H-, 13C- RMN. Compuşii sintetizaţi au fost testaţi ca inhibitori ai proliferării celulelor leucemice (HL-60), iar pentru produşii care au manifestat proprietăţi mai ponunţate, a fost testată in vitro activitatea lor antibacteriană faţă de unele microorganisme gram-pozitive şi gram-negative: Escherichia coli, Staphylococcus aureus, Shigella sonnei, Salmonella abony şi Bacillus cereus.
COORDINATION COMPOUNDS OF COBALT, NICKEL, COPPER, AND ZINC WITH N1,N2 -BIS(PYRIDIN-2-YLMETHYLIDENE)BENZENE-1,2-DIAMINE AND ITS DERIVATIVES
(2014) Pahonțu, Elena; Gulea, Aurelian; Poirier, Donald; Țapcov, Victor
o-Phenylenediamine reacts with 2-formyl-, 2-acetyl-, or 2-benzoylpyridine in ethanol in the presence of cobalt, nickel, copper, or zinc chlorides to form monomeric complexes ML1-3Cl2·nH2O {M = Co, Ni, Cu, Zn; L1 = N 1,N 2-bis(pyridin-2-ymethylidene)benzene-1,2-diamine, L2 = N 1,N 2-bis(pyridin-2-ylethylidene) benzene-1,2-diamine, L3 = N 1,N 2-bis[phenyl(pyridin-2-yl)methylidene]benzene-1,2-diamine; n = 0-3}. The condensation products (L1-L3) act in the complexes as tetradentate N,N,N,N-ligands. Thermolysis of the complexes occurs in two stages: dehydration (70-95°C) and complete degradation (320-450°C). At concentrations of 10-5-10-7 M, the complexes inhibit in vitro growth and proliferation of HL-60 human promyelocytic leukemia cells.
COORDINATION COMPOUNDS OF COPPER AND NICKEL WITH N,N'-[4,4'-(PERFLUORO-1,4-PHENYLENE)BIS(OXY)BIS(4,1-PHENYLENE)]- BIS[2-(PYRIDIN-2-YLMETHYLIDENE)HYDRAZINECARBOTHIOAMIDE] AND ITS DERIVATIVES
(2014) Pahonțu, Elena; Țapcov, Victor; Poirier, Donald; Gulea, Aurelian
N,N′-[4,4′-(Perfluoro-1,4-phenylene)bis(oxy)bis(4,1-phenylene)] bis[2-(pyridin-2-ylmethylidene)-hydrazinecarbothioamide] as well as its methyl and phenyl derivatives react with copper and nickel chlorides in ethanol to form coordination compounds. In the products, the hydrazinecarbothioamides act as doubly deprotonated bridging ligands. The prepared complexes have been found to inhibit in vitro the growth and propagation of the myeloid human leukemia HL-60 cancer cells at the 10-5-10-7 mol/L concentration.
THE CRYSTAL STRUCTURE AND ANTITUMOR ACTIVITY OF 1,6-DINITRATO-BIS[2-(5-METHYLSULFANYL)-4-(PROP-2-EN-1-YL)-4- -(1,2,4-TRIAZOL-3-YL)PYRIDINE]COPPER
(Academia de Ştiinţe a Moldovei, 2015) Petrenko, Peter A.; Graur, Vasilii О.; Chumakov, Yurii; Truhina, Irina; Tsapkov, Victor I.; Poirier, Donald; Gulea, Aurelian
CRYSTAL STRUCTURES OF NITRATO-{2-[2-(1-PYRIDINE-2-YLETHYLIDENE)HYDRAZINE]-1,3-BENZOTHIAZOLO}AQUACOPPER AND CHLORO-{2-[2-PHENYL(PYRIDINE-2-YLETHYLIDENE)HYDRAZINE]-1,3-BENZOTHIAZOLO}COPPER
(2015) Ciumacov, Iurie; Paholnițcaia, Anastasia; Petrenko, Peter A.; Țapcov, Victor; Poirier, Donald; Gulea, Aurelian
Two crystal modifications of nitrato-{2-[2-(1-pyridine-2-ylethylidene)hydrazine]-1,3-benzothiazolo}aquacopper (I and II) and two modifications of chloro-{2-[2-phenyl(pyridine-2-ylethylidene)hydrazine]-1,3-benzothiazolo}copper (III and IV) have been synthesized and studied by X-ray diffraction. In structures I and II, the copper atoms coordinate a monodeprotonated molecule of the organic ligand, nitrate ions, and a water molecule. In crystals of I, the complexes are monomeric, whereas complexes II are linked via nitrate ions to form polymeric chains. In both structures the coordination polyhedron of the copper atom can be described as a distorted tetragonal bipyramid—(4 + 1 + 1) in I and (4 + 2) in II. These coordination polyherdra have different compositions. In structures III and IV, the metal atoms coordinate a monodeprotonated {2-[2-phenyl(pyridine-2-ylethylidene)hydrazine]-1,3-benzothiazole molecule and chloride ions. In III the complex-forming ion has square-planar coordination geometry, whereas structure IV consists of centrosymmetric dimers with two bridging chlorine atoms. It was found that nitrato-{2-[2-(1-pyridine-2-ylethylidene)hydrazine]-1,3-benzothiazolo}aquacopper possesses antitumor activity.
IN VITRO ANTILEUKEMIA ACTIVITY (HL-60 CELLS), OF SOME 3d METAL COMPLEXES. CHEMICAL SYNTHESIS AND STRUCTURE – ACTIVITY RELATIONSHIP
(Academia de Ştiinţe a Moldovei, 2006) Gulea, Aurelian; Poirier, Donald; Roy, Jenny; Stavila, Vitalie; Bulimestru, Ion; Tsapkov, Victor; Bîrcă, Maria; Popovschi, Lilia
28 years after the first approval of cisplatin in the clinic against a number of cancer diseases, cisplatin and related compounds continue to be among the most efficient anticancer drugs used so far. Efforts are focused to develop novel platinum- and non-platinum-based antitumor drugs to improve clinical effectiveness, to reduce general toxicity and to broaden the spectrum of activity. Thiosemicarbazones and their transition metal complexes demonstrated potent cytotoxic activity against a series of murine and human suspended cultured tumor cells. The aim of our communication is to report the synthesis of novel 3d metal complexes with some di- and tri-dentate ligands containing N, O and S donor atoms which have different electronic and geometrical structure confirmed by elemental and thermal analyses, molar conductance, magnetic measurements, IR and NMR data. In order to investigate the antileukemia activity 27 metal complexes were tested as inhibitors of HL60 cells growing. It was established that the nature, electronic structure and coordination number of the central atom, the geometric configuration of metal complexes and the nature of the ligands (donor atoms) are important in biological activity prediction. In investigated series of complexes the most active are those having a copper (II) or a cobalt (II) species. For the octahedral environment of the cobalt complexes the electronic configuration is important Co2+ ( 3d7 ) > Co3+ ( 3d6 ). This different activity can be explained by the fact that in solutions Co2+ complexes with inner coordination sphere lifetime of the ligands 10-4 - 10-5 s are more labile in comparison with the inert Co3+ complexes (lifetime 103 – 105 s). Copper (II) complexes with different type of electronic hybridisation and geometric structure produce also different activity. We find that a square planar Cu2+ complexes have essential activity. The activity of such square planar complexes is influenced also by the nature of the ligand donor atoms. In fact complexes with coordinated ligands containing N, O and S chelate donor atoms are essentially more active than complexes including inner sphere only nitrogen or oxygen. In this case the presence of coordinated ligand containing sulphur donor atom is indicated. If sulphur ligand donor atom is blocked by CH3 group the biological activity became unsignificant.
IN VITRO ANTILEUKEMIA, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF SOME 3D METAL COMPLEXES: CHEMICAL SYNTHESIS AND STRUCTURE – ACTIVITY RELATIONSHIPS
(Taylor & Francis Open, 2008) Gulea, Aurelian; Poirier, Donald; Roy, Jenny; Stavila, Vitalie; Bulimestru, Ion; Tapcov, Victor; Birca, Maria; Popovschi, Lilia
The present paper describes the synthesis, characterization and in vitro biological evaluation screening of different classes (ammoniacates, dioximates, carboxylates, semi- and thiosemicarbazidates) of Co(II), Co(III), Cu(II), Ni(II), Mn(II), Zn(II) and Fe(III) complexes. Schiff bases were obtained from the reaction of some salicyl aldehydes with, respectively, furoylhydrazine, benzoylhydrazine, semicarbazide, thiosemicarbazide and S-methylthiosemicarbazide to give tridentate ligands containing ONO, ONS or ONN as donor atoms. The synthetic metal complexes are of various geometrical and electronic structures, thermodynamic and thermal stabilities, and magnetic and conductance properties. All complexes, except those of Cu, are octahedral. Some Cu, Co and Mn compounds have a dimeric or a polymeric structure. The composition and structure of complexes were analysed by elemental analysis, IR and 1 H NMR and 13C NMR spectroscopies, and magnetochemical, thermoanalytical and molar conductance measurements. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth, and the most potent, the Cu(II) complexes, have been also tested for their in vitro antibacterial and antifungal activities. Structure-activity relationships were carried out.
SUBSTITUTED 1,3-PHENYL(PYRIDYL) PROPENONES AND DERIVATIVES WITH THIOSEMICARBAZIDIC GROUPS. STRUCTRURE – (HL-60) ANTILEUKEMIA ACTIVITY RELATIONSHI
(Institute of Chemistry of ASM, 2014) Popuşoi, Ana; Barba, Nicanor; Gulea, Aurelian; Roy, Jenny; Poirier, Donald
3-(4-(Dimethylamino)phenyl-1-(4-isothiocyanatophenyl)prop-2-en-1-one was obtained from the corresponding N,N-dimethylthyoureas by elimination of dimethylamine at heating with gaseous hydrogen chloride in chloroform and 1-(4-isothiocyanatophenyl)-3-(pyridin-2-il)prop-2-en-1-one by treating 1,1-dimethyl-3-(4-(3-(pyridin-2-il)-acryloyl)-phenyl)thyourea with acetic anhydride. The difference in the reactivity of the groups >C=O and NCS in the synthesis with hydrazine hydrate and its derivatives allows the synthesis of some 1,3-disubstituted propenones with thiosemicarbazide groups (4- and 1,4-disubstituted) in good yields. From 4-substituted thiosemicarbazides and 2-formilpyridine thiosemicarbazones were obtained. In the case of some derivatives, the propenone group in the reaction with hydrazine hydrate allows the formation of pyrazole derivatives. All obtained compounds were investigated for antileukemia activity. It was found that this activity is more pronounced for thiosemicarbazide derivatives with two pyridine nuclei at concentrations 10-5-10-7 mol/L.
SUBSTITUTED 1,3-PHENYL(PYRIDYL) PROPENONES AND DERIVATIVES WITH THIOSEMICARBAZIDIC GROUPS. STRUCTRURE – (HL-60) ANTILEUKEMIA ACTIVITY RELATIONSHIP
(2014) Popușoi, Ana; Barba, Nicanor; Gulea, Aurelian; Roy, Jenny; Poirier, Donald
3-(4-(Dimethylamino)phenyl-1-(4-isothiocyanatophenyl)prop-2-en-1-one was obtained from the corresponding N,N-dimethylthyoureas by elimination of dimethylamine at heating with gaseous hydrogen chloride in chloroform and 1-(4-isothiocyanatophenyl)-3-(pyridin-2-il)prop-2-en-1-one by treating 1,1-dimethyl-3-(4-(3-(pyridin-2-il)-acryloyl)-phenyl)thyourea with acetic anhydride. For all obtained compounds in the course of reaction the antileukemia activity was investigated.
SULFANILAMIDE COPPER(II) CHELATES WITH 2-[(2-HYDROXYPHENYL-IMINO)METHYL]PHENOLOM AND 1-[(2-HYDROXYPHENYLIMINO)-METHYL]NAPHTHALEN-2-OL
(2010) Gulea, Aurelian; Țapcov, Victor; Poirier, Donald; Aruxandei, C.; Pahontu, Elena
2-[(2-Hydroxyphenylimino)methyl]phenol (H2L1) and 1-[(2-hydroxyphenylimino)methyl]naphthalen- 2-ol (H2L2) reacted with copper(II) acetate hydrate and sulfanilamide (Sf1), sulfathiazole (Sf2), sulfaethidole (Sf3), sulfadiazine (Sf4), and sulfadimidine (Sf5) in ethanol to give mixed-ligand copper chelates with the composition Cu(Sf1-5)(L 1-2) . nH2O (n = 1, 2). All these complexes are monomeric. Salicylaldehyde imines (H2L1 and H2L 2) behave as doubly deprotonated tridentate O,N,O ligands, whereas sulfanilamides (Sf1-5) are unidentate ligands. Thermolysis of the synthesized complexes includes dehydration at 70-90°C, followed by complete thermal decomposition (290-380°C). The complexes [Cu(Sf1)(L 1)] . 2H2O and [Cu(Sf3)(L1)] . H2O at a concentration of 10-4 M inhibited growth and reproduction of 100% of human myeloid leukemia cells (HL-60). The inhibitory effect was 90 and 75%, respectively, at a concentration of 10-5 M, whereas no antitumor activity was observed at a concentration of 10-6 M.
SULFANILAMIDE-CONTAINING COORDINATION COMPOUNDS OF Cu (II) WITH ISATIN AND N-METHYLISATIN THIOSEMICARBAZONES
(2006) Gulea, Aurelian; Spînu, S.; Țapcov, Victor; Poirier, Donald; Roy, Jenny
Isatin (L1) and N-methylisatin (L2) β-thiosemicarbazones react in ethanol with Cu(II) chloride and bromide in the presence of sulfanilamide (Streptocid, Sf1), N′- acetylsulfanilamide (Sulfacyl, Sf2), Norsulfazole (Sf3), Aethazolum (Sf4), and Sulfadimesine (Sf5) to form coordination compounds Cu(Sf1-5)L1-2X2· nH2O (X = Cl, Br; n = 2-5). All the complexes have a monomeric structure. Thiosemicarbazones L1 and L2 in these complexes are tridentate O,N,S ligands, and sulfanilamides Sf1-5 are monodentate ligands. Thermolysis of the substances involves the steps of dehydration (70-95°C) and complete decomposition (410-530°C).
SULFANYLAMIDE-CONTAINING COORDINATION COMPOUNDS OF 3d-ELEMENTS WITH 2,4-PENTANEDIONE BIS-THIOSEMICARBAZONE AND BIS-4-PHENYLTHIOSEMICARBAZONE
(2008) Gulea, Aurelian; Spînu, S.; Țapcov, Victor; Poirier, Donald
Thiosemicarbazide and 4-phenylthiosemicarbazide react in ethanol with 2,4-pentanedione in the presence of manganese, cobalt, nickel, copper, and zinc acetates hydrates and streptamin (Sf1), sulfaethidole (Sf 2), and sulfadimidine (Sf3) to form coordination compounds of the composition M(Sf1-3)(L1-2)·nH2O (M = Mn, Co, Ni, Cu, Zn; H2L1 is 2,4-pentanedione bis-thiosemicarbazone, H2L2 is 2,4-pentanedione bis-4-phenylthiosemicarbazone; n = 0-6). All the complexes synthesized are monomeric. Thiosemicarbazones (H2L1 and H 2L2) behave as twice deprotonated S,N,N,S-tetradentate ligands, while sulfanylamides (Sf1-3) act as monodentate ones. Thermolysis of these substances proceeds through the stages of dehydration (65-95°C) and complete thermal decomposition (430-560°C). It is found that the complex [Cu(Sf2)(L1)]·4H2O in the concentration 10-5 M inhibits the growth and fission of 100% cancer cells of the human myeloid leukemia (HL-60).
SYNTHESIS AND ANTILEUKAEMIA ACTIVITY OF N-(2,4-DIMETHYLPHENYL)HYDRAZINE CARBOTHIOAMIDE AND ITS AZOMETHINE DERIVATIVES
(2012) Gulea, Aurelian; Barba, Alic; Jalbă, Alexandru; Poirier, Donald; Petrenko, Peter A.; Ciumacov, Iurie; Sargun, Artur
Prezenta lucrare conţine date despre sinteza, caracterizarea şi evaluarea in vitro a activităţii biologice a N-(2,4-dimetilfenil)hidrazinocarbotioamidei şi a cinci derivaţi azometinici ai acesteia, obţinuţi prin condensarea N-(2,4-dimetilfenil)hidrazincarbotioamidei cu diferiţi compuşi carbonilici. Compoziţia şi structura cristalină a compuşilor sintetizaţi a fost determinată cu ajutorul spectroscopiei 1H, 13C RMN şi a difracţiei cu raze X a monocristalelor. Toţi compuşii obţinuţi au fost testaţi ca inhibitori ai proliferării celulelor de leucemie umană HL-60. A fost stabilit că N-(2,4-dimetilfenil)-2-(tiofen- 3-ilmetilen)hidrazinocarbotioamida şi N-(2,4-dimetilfenil)-2-(2-hidroxibenziliden) hidrazinocarbotioamida sunt cei mai activi agenţi antiproliferativi obţinuţi în acest studiu.
SYNTHESIS AND ANTILEUKAEMIA ACTIVITY OF N-(2,4-DIMETHYLPHENYL)HYDRAZINECARBOTHIOAMIDE AND ITS AZOMETHINE DERVIATIVES
(Academia de Ştiinţe a Moldovei, 2017) Erhan, Tatiana; Jalba, Svetlana; Sargun, Artur; Barba, Alic; Poirier, Donald; Gulea, Aurelian; Pahontu, Elena
SYNTHESIS AND ANTIPROLIFERATIVE ACTIVIT Y OF 5-PYRAZOLONE DERIVATIVES AND THERE CU(II), NI(II), CO(II) AND V(V) COMPLEXES
(2018) Pahontu, Elena-Mihaela; Poirier, Donald; Gulea, Aurelian
Complex combinations of Cu(II), Ni(II), Co(II) and V(V) with thiosemicarbazone derivatives of 1-phenyl3-methyl-4-benzoyl-5-pyrazolone-4-R-thiosemicarbazone (where R = CH3, C2H5, C6H5, C5H5N) were synthesized. The characterization of the newly formed compounds was done by 1H NMR, 13C NMR, IR, UV–Vis spectroscopy, elemental analysis, molar electric conductibility, magnetic susceptibility measurements and thermal analysis. For the copper(II) complexes metal–ligand bonding parameters have been evaluated from the EPR spectra. In addition, the structures of the ligands ( HL1-3) and its copper(II) (1, 6, 8, 12), nickel(II) (3, 13) and vanadium(V) (9) complexes were determined by single-crystal X-ray diffraction. The composition of the coordination polyhedron of the central atom in complexes is different. The complexes and ligands were tested for their in vitro antiproliferative activity on human leukemia HL-60. Antiproliferative activity of copper(II) complexes (1, 2, 5 - 8, 11, 12, 15, 16 ) at 10 μM is similar to doxorubicin, used in medical practice as antileukemia drug. The IC50 values were found to be 0.24 μM for complex 2, 0.3 μM for complex 6 and 0.36 μM for complex 11 reveal the potential antiproliferative of these compounds.
SYNTHESIS AND BIOLOGIC PROPERTIES OF SOME1-(ALCHYL) PHENYL-3-(4-(3-(PYRIDIN-2-IL)ACRYLOYL)PHENYLTHIOUREA
(2013) Popușoi, Ana; Barba, Nicanor; Gulea, Aurelian; Roy, Jenny; Poirier, Donald; Prisacari, Viorel
This paper describe the synthesis of some 1-(alchyl)aril-3-(4-(3-pyridin-2-il) acryloyl)phenylthiourea obtained by condensation of 2-pyridincarboxaldehide with some derivatives of 4-acetylphenilthioureas in basic medium or by addition of aliphatic and aromatic amines to the correspondingisothiocyanatopropenones. 12 new compounds were obtained and their biological properties were analysed. The substituted thioureas by pyridine radicals, morpholine and phenol show a maximum bacteriostatic activity for Gram positive microorganisms like: Staphylococcus Aureus and Enterococcus Faecalis at the minimum inhibitory concentration 9.37-37.5 μM. Antifungal activity for Candida Albicans, Aspergillus Niger, AspergillusFumigatus, Penicillium is weak, in minimum inhibitory concentration 600->600 μM. The leukemia activity like inhibitor (HL-60), is 84-96.9% at the concentration 10-5mol/l and 15-20% and at the concentrations 10-6, 10-7mol/l.
SYNTHESIS AND CHARACTERIZATION OF NOVEL CU(II), PD(II) AND PT(II) COMPLEXES WITH 8-ETHYL-2-HYDROXYTRICYCLO(7.3.1.02,7)TRIDECAN-13-ONE- THIOSEMICARBAZONE: ANTIMICROBIAL AND IN VITRO ANTIPROLIFERATIVE ACTIVITY
(2016) Pahonțu, Elena; Paraschivescu, Codruța; Ilieș, Diana Carolina; Poirier, Donald; Oprean, Camelia; Păunescu, Virgil; Gulea, Aurelian; Roșu, Tudor; Bratu, Ovidiu
New Cu(II), Pd(II) and Pt(II) complexes, (Cu(L)(H2O)2(OAc)) (1), (Cu(HL)(H2O)2(SO4)) (2), (Cu(L)(H2O)2(NO3)) (3), (Cu(L)(H2O)2(ClO4)) (4), (Cu(L)2(H2O)2) (5), (Pd(L)(OAc))H2O (6), and (Pt(L)2) (7) were synthesized from 8-ethyl-2-hydroxytricyclo(7.3.1.02,7)tridecan-13-one thiosemicarbazone (HL). The ligand and its metal complexes were characterized by IR, 1H-NMR, 13C-NMR, UV-Vis, FAB, EPR, mass spectroscopy, elemental and thermal analysis, magnetic susceptibility measurements and molar electric conductivity. The free ligand and the metal complexes have been tested for their antimicrobial activity against E. coli, S. enteritidis, S. aureus, E. faecalis, C. albicans and cytotoxicity against the NCI-H1573 lung adenocarcinoma, SKBR-3 human breast, MCF-7 human breast, A375 human melanoma and HL-60 human promyelocytic leukemia cell lines. Copper complex 2 exhibited the best antiproliferative activities against MCF-7 human breast cancer cells. A significant inhibition of malignant HL-60 cell growth was observed for copper complex 2, palladium complex 6 and platinum complex 7, with IC50 values of 1.6 μM, 6.5 μM and 6.4 μM, respectively.
Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity
(Molecular Diversity Preservation International (MDPI), 2013) Pahonțu, Elena; Fala, Valeriu; Gulea, Aurelian; Poirier, Donald; Tapcov, Victor; Rosu, Tudor
Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1–32) with salicylidene thiosemicarbazones (H2L1–H2L10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C6H5). The characterization of the new formed compounds was done by 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.
SYNTHESIS AND CHARACTERIZATION OF SOME NEW CU(II), NI(II) AND ZN(II) COMPLEXES WITH SALICYLIDENE THIOSEMICARBAZONES: ANTIBACTERIAL, ANTIFUNGAL AND IN VITRO ANTILEUKEMIA ACTIVITY
(2013) Pahonțu, Elena; Fala, Valeriu; Gulea, Aurelian; Poirier, Donald; Țapcov, Victor; Roșu, Tudor
Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1-32) with salicylidene thiosemicarbazones (H2L1-H2L10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C6H5). The characterization of the new formed compounds was done by 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF NOVEL CU(II), PD(II), PT(II) COMPLEXES WITH 2-HYDROXY-8-ETHYLTRICYCLO[7.3.1.0.2,7]TRIDECANE-13-ONE THIOSEMICARBAZONE
(Academia de Ştiinţe a Moldovei, 2015) Pahontu, Elena Mihaela; Paraschivescu, Codruta; Ilies, D.; Poirier, Donald; Oprean, Camelia; Gulea, Aurelian; Roşu, Tudor