Browsing by Author "Poirier, D."

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    COORDINATION COMPOUNDS OF COBALT, NICKEL, COPPER, AND ZINC WITH N1 ,N2 -BIS(PYRIDIN-2-YLMETHYLIDENE)BENZENE-1,2-DIAMINE AND ITS DERIVATIVES
    (Pleiades Publishing Ltd., 2014) Pahonțu, Elena; Gulea, Aurelian; Poirier, D.; Tsapkov, V. I.
    о-Phenylenediamine reacts with 2-formyl-, 2-acetyl-, or 2-benzoylpyridine in ethanol in the presence of cobalt, nickel, copper, or zinc chlorides to form monomeric complexes ML1−3 Сl2·nH2O {M = Co, Ni, Cu, Zn; L1 = N1,N2 -bis(pyridin-2-ymethylidene)benzene-1,2-diamine, L2 = N1,N2-bis(pyridin-2-ylethylidene)benzene-1,2-diamine, L3 = N1,N2 -bis[phenyl(pyridin-2-yl)methylidene]benzene-1,2-diamine; n = 0–3}. The condensation products (L1−L3) act in the complexes as tetradentate N,N,N,N-ligands. Thermolysis of thecomplexes occurs in two stages: dehydration (70–95°С) and complete degradation (320–450°С). At concentrations of 10–5–10–7 M, the complexes inhibit in vitro growth and proliferation of HL-60 human promyelocytic leukemia cells.
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    CRYSTAL STRUCTURES OF 5-BROMO-2-HYDROXYBENZALDEHYDE, 2-HYDROXY-3-METHOXYBENZALDEHYDE, AND 2-HYDROXYNAPHTHALENE- 1-CARBALDEHYDE 4-(2-PYRIDYL) THIOSEMICARBAZONES
    (MAIK Nauka/Interperiodica, 2014) Chumakov, Yu. M.; Petrenko, P. A.; Codita, T. B.; Tsapkov, V. I.; Poirier, D.; Gulea, Aurelian
    5-Bromo-2-hydroxybenzaldehyde,2-hydroxy3-ethoxybenzaldehyde,and 2-hydroxynaphthalene-1-carbaldehyde 4-(2-pyridyl) thiosemicarbazones (I–III, respectively) were synthesized and theircrystal structures were determined by X-ray diffraction. All these molecules are almost planar. The presenceof bulky substituents at the terminal nitrogen atoms of these molecules does not lead to changes in the conformation of the thiosemicarbazide moiety. Depending on the nature of substituents in the phenol rings, thecrystals are composed of either centrosymmetric dimers (I) or infinite chains (II and III. In the concentration range of 10–5–10–7 mol/L, thiosemicarbazones I–III selectively inhibit the growth of human myeloidleukemia HL60 cells.