Browsing by Author "Munteanu, Viorel"

Now showing 1 - 3 of 3

INFORMATION TOOL FOR NEW GENERATION SEQUENCE DAT A INTERPRETATION
(CEP USM, 2021) Munteanu, Viorel; Mertea, Rodica; Duca, Maria
The completion of the Human Genome project, which described the sequence of nucleotides in the DNA molecule and identified about 3 billion pairs of nucleotides for a total of about 23,000 to 25,000 genes, personalized medicine became a major challenge for biomedicine. Every year, researchers identify new genes associated with certain patholog ies, then create and test new drugs that target the activity of these genes. Moreover, approximately 150 - 200 genetic tests are used in clinical practice and tests have been developed that include gene panels for many of the most common polygenic diseases. An important role in the development of genomics - based therapies and testing of predisposition to certain diseases lies in molecular analysis techniques, including the development and implementation of state - of - the - art sequencing (SNG) technologies, which have changed the perspectives of analysis and understanding of living beings generally, including allows the assessment of genome variability in populations. The challenge in reporting SNG results appears at the intersection between the necessary and usefu l information for personalized medicine, regarding the appropriate level of detail, so that the use and limitations of the analysis are clearly understood by the user. The time required to evaluate an SNG test can vary between hours and weeks. The final st age of the analysis is represented by the elaboration of the resulting clinical report. The clinical report of SNG results must contain sufficient information to communicate the results of the test and its limitations.
NFORMATION TOOL FOR NEW GENERATION SEQUENCE DATA INTERPRETATION
(CEP USM, 2021) Munteanu, Viorel; Martea, Rodica; Duca, Maria
PLANTELE MEDICINALE DIN FLORA SPONTANĂ A REPUBLICII MOLDOVA ASPECTE MODERNE DE CERCETARE
(Gradina Botanică (Institut) a AŞM, 2011) Duca, Maria; Port, Angela; Muller-Uri, Frieder; Leviţchi, Alexe; Budeanu, Oleg; Mârza, Mihai; Munteanu, Viorel; Ţapu, Lucia
Medical plants represent an important resource of vegetal drugs and biological active compounds. Nowadays, it is recommended to integrate application of traditional medicine with modern one, especially regarding scientifi c research and assessment of natural drugs. Usage of local plants in medicine is a prospective and economically important direction. Flora of Republic of Moldova includes a vast diversity of species with opportunity to be applied in treatment of cardiovascular diseases, infections, oncology etc. But, for their exploitation it is necessary to apply modern technologies of research, which generates new knowledge for rational breeding of medical plants, extraction of pharmacologic substances and drug production. Articles present a synthesis of information on medicinal plants found in Moldova, biological aspects of their care. It evaluated the potential number of species and the posibility to store them in a database. One of the prospects for recovery of plant genetic fund may be provided by genotyping of medicinal plants by molecular biology techniques and bioinformatics analysis.