Browsing by Author "Jalbă, Angela"
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Item SINTEZA ŞI CARACTERISTICA HIDRAZONELOR OBŢINUTE ÎN BAZA 2-HIDRAZINOBENZOTIAZOLULUI CU PROPRIETĂŢI ANTIMICROBIENE ŞI ANTIPROLIFERATIVE(CEP USM, 2012) Paholniţcaia, Anastasia; Barbă, Nicanor; Gulea, Aurelian; Jalbă, Angela; Lozan-Tîrşu, CarolinaNine hydrazones have been obtained on the basis of 2-hydrazinobenzothiazole. The obtained hydrazones inhibits the growth of HL-60 cells of human leukemia myeloid within the concentrations of 10-5-10-6 mol/l. The highest activity showed the compounds obtained on the basis of carboxy-2-pyridine and less activity on the basis of salicylic aldehyde. The properties of compounds represent an interest for medicine in terms of expanding of an arsenal of inhibitors of human leukemia HL-60 myeloid. The hydrazones manifest comparable activity with such drugs as doxorubicin (Doxo) used in medicine for the leukemia treatment. The replacement of pycolidinic fragment of azomethine with salicylidinic fragment increase the antimicrobial activity, and with dimethilaminobenzenic fragment decreases the microbial activity. The greater sensitivity in comparison with synthesized substances has expressed gram-positive microorganisms (Staphylococcus aureus (ATCC 25923), Bacillus cereus (ГИСК 8035)).Item SYNTHESIS AND BIOLOGICAL ACTIVITY OF COPPER(II) COMPLEXES OF 2-FORMYLPYRIDINE 4-(DIMETHYLPHENYL)THIOSEMICARBAZONES(Academia de Ştiinţe a Moldovei, 2012) Sargun, Artur; Jalbă, Angela; Lozan-Tîrşu, Carolina; Gulea, Aurelian; Sofroni, Larisa; Stefan-van Staden, Raluca-Ioana; Bîrcă, MariaItem SYNTHESIS, STRUCTURE, ANTITUMOR AND ANTIMICROBIAL ACTIVITY OF 3D-METAL COMPLEXES WITH SOME DERIVATIVES OF PYRIDINE-2- CARBALDEHYDE 4-(PYRIDINE-2-YL)THIOSEMICARBAZONES(Academia de Ştiinţe a Moldovei, 2012) Căpăţînă, Tatiana; Jalbă, Angela; Zariciuc, Elena; Sofroni, Larisa; Sofroni, Dumitru; Tsapkov Victor I.; Gulea, Aurelian