Browsing by Author "Chumakov, Yurie"

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    ANTIBACTERIAL, ANTIFUNGAL AND IN VITRO ANTILEUKAEMIA ACTIVITY OF METAL COMPLEXES WITH THIOSEMICARBAZONES
    (Wiley, 2015) Pahonțu, Elena; Julea, Felicia; Rosu, Tudor; Purcarea, Victor; Chumakov, Yurie; Petrenco, Petru; Gulea, Aurelian
    1-phenyl-3-methyl-4-benzoyl-5-pyrazolone 4-ethyl-thiosemicarbazone (HL) and its copper(II), vanadium(V) and nickel(II) complexes: [Cu(L)(Cl)]·C2H5OH·(1), [Cu(L)2]·H2O (2), [Cu(L)(Br)]·H2O·CH3OH (3), [Cu(L)(NO3)]·2C2H5OH (4), [VO2(L)]·2H2O (5), [Ni(L)2]·H2O (6), were synthesized and characterized. The ligand has been characterized by elemental analyses, IR, 1H NMR and 13C NMR spectroscopy. The tridentate nature of the ligand is evident from the IR spectra. The copper(II), vanadium(V) and nickel(II) complexes have been characterized by different physico-chemical techniques such as molar conductivity, magnetic susceptibility measurements and electronic, infrared and electron paramagnetic resonance spectral studies. The structures of the ligand and its copper(II) (2, 4), and vanadium(V) (5) complexes have been determined by single-crystal X-ray diffraction. The composition of the coordination polyhedron of the central atom in 2, 4 and 5 is different. The tetrahedral coordination geometry of Cu was found in complex 2 while in complex 4, it is square planar, in complex 5 the coordination polyhedron of the central ion is distorted square pyramid. The in vitro antibacterial activity of the complexes against Escherichia coli, Salmonella abony, Staphylococcus aureus, Bacillus cereus and the antifungal activity against Candida albicans strains was higher for the metal complexes than for free ligand. The effect of the free ligand and its metal complexes on the proliferation of HL-60 cells was tested.
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    CRYSTAL STRUCTURE OF [2-(2-HYDROXYBENZILYDENE)- HYDRAZINECARBOXOAMIDATO(1-)][2-(2-HYDROXYBENZILYDENE)- HYDRAZINECARBOXOAMIDATO(2-)]CHROMIUM MONOHYDRATE
    (MAIK Nauka/Interperiodica, 2013) Chumakov, Yurie; Tsapkov, V. I.; Petrenko, P. A.; Gulea, Aurelian; Palomares-Sànchez, S. A.
    The crystal structure of [2-(2-hydroxybenz lydene)hydrazinecarboxoamidato(1-)][2-(2-hydroxy- benzilydene)hydrazinecarboxoamidato(2-)]chromium monohydrate [Cr(HL)(L)]⋅H2O (I), where H2L is salicylaldehyde semicarbazone, is determined. In I the central chromium atom is octahedrally surrounded by two ligand anions in the mer position and coordinated azomethine nitrogen atoms, phenol and carbamide oxygen atoms. In both ligands phenol groups are deprotonated; in one of them the imine group is also deprotonated. In the crystal, complexes of the compound studied are hydrogen bonded into layers along the [100] direction, with π–π stacking being observed between the phenyl rings inside the layer along with the X–Н⋯Cg (π ring) interaction.