Browsing by Author "Chumakov, Yu. M."

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    CRYSTAL STRUCTURES OF 5-BROMO-2-HYDROXYBENZALDEHYDE, 2-HYDROXY-3-METHOXYBENZALDEHYDE, AND 2-HYDROXYNAPHTHALENE- 1-CARBALDEHYDE 4-(2-PYRIDYL) THIOSEMICARBAZONES
    (MAIK Nauka/Interperiodica, 2014) Chumakov, Yu. M.; Petrenko, P. A.; Codita, T. B.; Tsapkov, V. I.; Poirier, D.; Gulea, Aurelian
    5-Bromo-2-hydroxybenzaldehyde,2-hydroxy3-ethoxybenzaldehyde,and 2-hydroxynaphthalene-1-carbaldehyde 4-(2-pyridyl) thiosemicarbazones (I–III, respectively) were synthesized and theircrystal structures were determined by X-ray diffraction. All these molecules are almost planar. The presenceof bulky substituents at the terminal nitrogen atoms of these molecules does not lead to changes in the conformation of the thiosemicarbazide moiety. Depending on the nature of substituents in the phenol rings, thecrystals are composed of either centrosymmetric dimers (I) or infinite chains (II and III. In the concentration range of 10–5–10–7 mol/L, thiosemicarbazones I–III selectively inhibit the growth of human myeloidleukemia HL60 cells.
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    CRYSTAL STRUCTURES OF [N′-(2- OXIDOBENZYLIDENE)-N-(PROP-2-EN-1-YL)- CARBAMOHYDRAZONOTHIOATO(2-)](1,10- PHENANTHROLINE)COPPER AND [N′-(2- OXIDOBENZYLIDENE)-N-(PROP-2-EN-1-YL)- CARBAMOHYDRAZONOTHIOATO(2-)](2,2′- BIPYRIDINE)COPPER HEMIHYDRATES
    (2022) Chumakov, Yu. M.; Graur, V. O.; Ulchina, Ya. I.; Smaglii, V. A.; Gulea, A. P.; Garbuz, O. S.; Tsapkov, V. I.
    The crystal structures and biological properties of [N′-(2-oxidobenzylidene)-N-(prop-2-en-1-yl)-carbamohydrazonothioato(2-)](1,10-phenanthroline)copper hemihydrate [Cu(1,10-Phen)(L)]·0.5H2O (I) and [N′-(2-oxidobenzylidene)-N-(prop-2-en-1-yl)-carbamohydrazonothioato(2-)](2,2′-bipyridine)copper hemihydrate [Cu(2,2′-BPy)(L)]·0.5H2O (II), where Н2L is 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide, are determined. The asymmetric unit of the unit cell in the crystal structures of I and II contains a copper complex with bidentate amine and a ligand coordinated by the azomethine nitrogen atom, the deprotonated phenolic oxygen atom, and the sulfur atom in the thiol form. The coordination polyhedron of the copper atom in compounds I and II is a distorted tetragonal pyramid. Obtained coordination compounds I and II exhibit antimicrobial and antifungal activities and have minimum inhibitory concentration and bactericidal concentration values in a range of 1.5-500 µg/mL. The study of the antioxidant activity shows that compounds I and II are less active than uncoordinated thiosemicarbazone H2L, but more active than trolox used in medical practice.