Browsing by Author "Botnaru, Maria"

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    Compounds removed from the condensation reaction between 2-acetylpyridine and 2-formylpyridine [Articol]
    (Institutul de Chimie al AŞM, 2020) Rusnac, Roman; Botnaru, Maria; Barba, Nicanor; Petrenko, Peter; Chumakov, Yurii; Gulea, Aurelian
    The research is devoted to the study of unexpected products that formed as a result of the condensation reaction between 2-acetylpyridine and 2-formylpyridine under the Claisen-Schmidt reaction conditions. The structure of the compoundswas determined and confirmed using FTIR, 1H and 13 C NMR spectroscopy, and X-ray diffraction technique. As a result, a sequence of reactions leading to the following compounds has been proposed: 1,3-bis(pyridin-2-yl)prop-2-en-1-one (3); 1,3,5-tri(pyridin-2-yl)pentane-1,5-dione (4); (2,4-dihydroxy-2,4,6-tri(pyridin-2-yl)cyclohexyl)(pyridin-2-yl)methanone (5) and (4-hydroxy-2,4,6-tri(pyridin-2-yl)cyclohexane-1,3-diyl)bis(pyridin-2-ylmethanone) (6) as well as2- formylpyridine (1) and 2-acetylpyridine (2). The plausible mechanisms of these chemical transformations and synthetic methods for obtaining substituted cyclohexanol derivatives are also presented. The synthesized compounds were tested for antimicrobial and antioxidant activity. The obtained results show that the compounds 4-6have moderate antifungal activity. The activity of compound 6is nine times higher towards Cryptococcus neoformans than the activity of Nistatinthat is used in medical practice. The present experimental results show that compound 6has potential application in antibacterial and antifungal areas.
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    Lucrări practice la chimia organică pentru specialităţile: tehnologia chimică, tehnologia produselor cosmetice şi medicinale, protecţia mediului, securitatea ecologică, biologie, ecologie şi pedologie
    (CEP USM, 2016) Dragalina, Galina; Botnaru, Maria; Popușoi, Ana
    Indicațiile metodice pentru LUCRĂRI PRACTICE LA CHIMIA ORGANICĂ reprezintă materialul didactic obligatoriu întru asigurarea aspectului experimental care, conform curriculumului, însoțește disciplinele Bazele teoretice ale chimiei organice și stereochimie (30 de ore curs și 60 de ore lucrări practice, anul I, semestrul I) și Chimia compușilor naturali (30 de ore curs și 60 de ore lucrări practice, anul I, semestrul II) în cadrul Facultății de Chimie și Tehnologie Chimică. Materialul de față asigură de asemenea cursul teoretic Chimie organică de la Facultatea de Biologie și Pedologie (15 ore curs, 45 de ore lucrări practice, anul I, semestrul I). Lucrarea prezentată este destinată studenților anului I de la specialitățile: tehnologia chimică, tehnologia produselor cosmetice şi medicinale, protecţia mediului, securitatea ecologică, biologie, ecologie şi pedologie.
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    Sorbţia vitaminei C pe cărbuni activi [Articol]
    (CEP USM, 2021) Guţanu, Vasile; Botnaru, Maria; Baerle, Natalia
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    Structure of 2-[-3-(4-methylphenyl)-1-(pyridin-2-YL)prop-2-en-1-ylidene]hydrazine-1-carbothioamide [Articol]
    (2018) Rusnac, R.; Petrenco, P.; Chumakov, Yu.; Botnaru, Maria; Gulea, Aurelian
    During the recent years, a large number of chalcone-derived thiosemicarbazones are found to have potential therapeutic applications. They possess diverse biological activities including anti-inflammatory, antimicrobial and as cell growth inhibitor. It was found that the biological properties of these complexes correlate with their structures and the metal coordination leads to an improvement of chalcone-thiosemicarbazones pharmacological activities and synergistic effects. The aim of this work is the synthesis and the determination of structural and biological properties of 2-[-3-(4-methylphenyl)-1-(pyridin-2-yl)prop-2-en-1-ylidene]hydrazine-1-carbothioamide (I). In C=N-NH-CS backbone of I the S atom is in trans to azomethine N atom. This core of the studied ligand is essentially planar within 0.01 Ǻ. In I the dihedral angles of aromatic rings with mentioned backbone are equal to 30.0 and 32.2° respectively. In the crystal the molecules form the centro symmetric dimers via N-HS hydrogen bonds which in turn join through the N-H…N H-bonds. The synthesized compound I shows the moderate inhibition of HeLa, BxPC-3, TC-1 cancer cells in the range of concertation of 10-1 μM.
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    Synthesis and biological activity of copper, nickel, and cobalt coordination compounds of condensation products of some chalcones with 4-phenylthiosemicarbazide [Articol]
    (Academia de Ştiinţe a Moldovei, 2015) Tsapkov, Victor I.; Boeva, Maria; Botnaru, Maria; Garbuz, Olga; Gulea, Aurelian; Gudumac, Valentin
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    Tratament termic al cărbunelui activ încărcat cu vitamina C [Articol]
    (CEP USM, 2022-11-10) Guţanu, Vasile; Botnaru, Maria; Sîrbu, Angela;