Browsing by Author "Balan, Ion"

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ADVANTAGES OF CRYOCONSERVATION OF SPERM IN REPRODUCTIVE BIOTECHNOLOGY
(CEP USM, 2022-09-29) Roșca, Nicolae; Balan, Ion; Balacci, Sergiu; Buzan, Vladimir; Crețu, Roman; Moroz, Mihail; Osipciuc, Galina; Bacu, Gheorghe
DIRECTING THE GROWTH OF CARP LARVAE THROUGH THE APPLICATION OF THERMAL FACTOR
(CEP USM, 2022-09-29) Balacci, Sergiu; Balan, Ion; Buzan, Vladimir
Echilibrul fiziologic al organismuli în funcție de influența stresului termic
(Editura USM, 2024) Moroz, Mihail; Balan, Ion; Donica, Gheorghe; Cociu Valeriu; Starciuc, Nicolae; Mațencu, Dmitrii; Voinițchi, Eugen; Gurdiș, Viorica; Ceban, Elena
Heat stress is a major challenge and is one of the main environmental stressors with substantial economic losses in the rabbit industry. Rabbits are more sensitive to heat stress, compared to other agricultural animals, because they have few sweat glands, and their body is covered with thick fur. Heat stress negatively influences the health of rabbits, their reproductive properties, growth and productivity, characteristics of rabbit products, antioxidant properties, immune response, histomorphology and intestinal microbiota. Currently, one of the real strategies for mitigating the unfavorable influences of heat stress can be the use of nutraceuticals with targeted properties in improving the development of the intestinal microbiota, enhancing antioxidant properties, stimulating the immune system, increasing the productivity and resistance of the rabbit's body to diseases, in the physiological maintenance of the chemical composition and biophysical characteristics of rabbit products. This article summarizes the recent information on the negative impact of increased temperatures on rabbits and the advantages of heat stress mitigation strategies.
EVOLUȚIA TEHNICILOR DE EVALUARE ALE MATERIALULUI SEMINAL ÎN DETERMINAREA FERTILITĂȚII MASCULINE
(CEP USM, 2022-11-10) Balan, Ion; Balacci, Sergiu; Roşca, Nicolae; Buzan, Vladimir; Furdui, Vlada; Mereuţă, Ion; Harea, Vasile; Hanțațuc, Alexei; Vîhrist, Ecaterina; Temciuc, Vlad
IMPACTUL FACTORILOR ALIMENTARI ȘI METABOLICI ÎN REPRODUCEREA INDUSTRIALĂ A PĂSĂRILOR
(CEP USM, 2024) Petcu, Igor; Balan, Ion; Demcenco, Boris; Roşca, Feodora; Gramovici, Ana
For the economic efficiency of the poultry breeding industry, it is necessary to create and physiologically maintain the metabolism of the organism of the breeding flock according to the food variety. The main task of industrial poultry farming is the development and testing of bio logically active, economical and ecological feed substances that increase the reproductive pro perties and productivity of birds. One of the basic objectives in industrial poultry farming is to know, reveal and elucidate the biological, physiological and metabolic essence of the enhanced reproductive capacities of the parental stock. Thus, the effectiveness of industrial reproduction of birds is directly proportional to the development of technological, food and sexual disorders, which trigger interstitial metabolism dysfunctions. In this sense, great attention must be paid to the development and implementation of technologies capable of mitigating the consequences of metabolic dysfunctions. One of these approaches is systemic dietary, nutritional and pharma cological prophylaxis of metabolic disorders in birds of reproductive age.
INFLUENȚA FACTORILOR INTRINSECI ȘI EXTRINSECI ASUPRA DEZVOLTĂRII CELULELOR SOMATICE ȘI GERMINALE
(CEP USM, 2024) Balan, Ion; Gavojdian, Dinu; Roşca, Nicolae; Balacci, Serghei; Buzan, Vladimir; Furdui, Vlada; Osipciuc, Galina; Harea, Vasile
Mammalian spermatogenesis is the most complex regulated process of cell development and represents a specific physiological process for the study of the peculiarities of the mechanism of spermatogenesis and for perceiving the basic evolution of all developmental processes, since it involves specific molecular processes of somatic and sex cells. Spermatogenesis generates spermatozoa from spermatogonal stem cells through several stages and comprises spermatocytogenesis, meiosis and spermiogenesis with the continuous unfolding of molecular events of mitosis, meiosis and epigenetic dynamic changes at the morphological and molecular level. Spermatogenesis establishes some dynamic changes by overlapping the functions of different types of cells and is maintained by different physiological factors impacting testicular morphofunction. The existing overlaps complicate the conclusive elucidation of the individual roles of different somatic and germ cells in the self-renewal, proliferation and apoptosis of spermatogonial stem cells and create difficulties in understanding the contribution of distinct signaling molecules during spermatogenesis. Several factors, compounds secreted by all somatic cells, including Sertoli cells, peritubular myoid cells and Leydig cells are involved in the regulation and development of spermatogenesis, but the mechanisms by which these factors interact in somatic and germ cells are largely unknown and a comprehensive study of these cells is needed.
INFLUENȚA MEDIULUI ZAHAROZĂ, DULCIT, ARGININĂ ȘI VITAMINA B6 PENTRU CONSERVAREA SPERMEI UMANE
(CEP USM, 2024) Cazacov, Iulia; Balan, Ion; Roşca, Nicolae; Buzan, Vladimir; Mereuța, Ion; Bucarciuc, Melania
Au fost studiați indicii fiziologici care caracterizează sperma sanogenă de om prin conservare cu folosirea argininei și vitaminei B6 în componența mediului de zaharoză și dulcit. În rezultatul cercetărilor, diluantul cu conținut de vitamina B6 1,6 mg și arginină 0,29 mg, pe bază de zaharoză, dulcit-glicerină-gălbenuș și apă distilată după congelare-decongelare a celulelor sexuale umane, posedă indici fiziologici care caracterizează sperma sanogenă procentual (mobilitatea 29,7 %, indicile absolut al supraviețuirii 93,6 % și longevitatea 28,3%) mai sporit comparativ cu lotul martor
INFLUIENȚA EXTRACTULUI DE POLIFENOLI DIN NUCILE VERZI ASUPRA METABOLISMULUI GLUTATIONULUI DIN SERIUL SANGUIN AL COCOȘILOR
(CEP USM, 2024) Roșca, Nicolae; Balan, Ion; Buzan, Vladimir; Balacci, Sergiu; Furdui, Vlada; Mereută, Ion; Osipciuc, Galina; Crețu, Roman; Bacu, Gheorghii
In this paper, the influence of polyphenol extract from green walnuts on glutathione metabo lism in the blood serum of breeding roosters was studied. To achieve this purpose, hydroalcoholic extract from green walnuts was used, with a total antioxidant activity of 548,37 mg gallic acid equivalent/100 gr. For the study were used two batches of roosters, of five animals in each batch, experimental and control. As a result of the research on the influence of metabolism, changes were obtained in the content of SH-groups, G-TP, G-S-T, as well as amino acids, which are part of the glutathione composition and which were studied in different biological fluids and repro ductive cells. The basic mechanism of the central role of thiol-mediated redox control in cellular metabolism is the ability of thiol groups to reversibly change their redox state with subsequent changes in the conformational, catalytic or regulatory functions of the protein.
Morfofuncționalitatea mitocondrială în evoluția spermatogenezei la mamifere
(Editura USM, 2024) Balan, Ion; Surai, Peter; Marin, Paula Monica; Balacci, Sergiu; Roșca, Nicolae; Buzan, Vladimir; Petcu, Igor; Mereuță, Ion; Osipciuc, Galina; Popa, Valerian; Vîhrist, Ecaterina
In spermatogenesis, mitochondria are particularly important for the development and maintenance of germ cells and the production of healthy gametes. Deficiencies in these processes lead to mitochondrial dysfunction and abnormal spermatogenesis. The classical roles of mitochondria in energy production, metabolism and apoptosis have been well defined, but they also have various other functions. Mitochondria are also involved in testosterone production, regulating proton secretion in the lumen to maintain an acidic state in the epididymis, and condensing sperm DNA. In the available literature on sperm mitochondria, it is increasingly recognized that the morphology and functional status of mitochondria has a significant impact on sperm characteristics. Although mitochondria are recognized as essential for sperm, their exact pathophysiological role and functioning are complex. Understanding and managing mitochondrial quality control could be a valuable approach for developing new strategies in the physiological evolution of spermatogenesis.
PHOTOVOLTAIC MINIMODULE BASED ON CdTe
(2006) Potlog, Tamara; Ghimpu, Lidia; Balan, Ion
CdS/CdTe solar cells were fabricated without antireflection coatings by successive growth without intermediate processing from the close space sublimation of CdS and CdTe thin layers on conductive and transparent SnO2/glass substrates. At 300 K and 100 mW/cm2the following best photoelectric parameters were obtained: Isc= (18-19)mA/cm2 and Voc=(0,80-0,82)V. The conversion efficiency is around 10%. The quantum efficiency (QE) in the 510 nm and 845 nm range of wavelengths is on the order of 80-85%. The minimodule fabricated on the basis of the CdTe cells shows power of 0.45 W, corresponding to a voltage of 3 V, and current of 150 mA.
Proprietățile celulelor stem spermatogoniale în mediul nișelor fiziologice și metabolice testiculare
(Editura USM, 2024) Balan, Ion; Gavojdian, Dinu; Budevici, Alexandr; Roșca, Nicolae; Buzan, Vladimir; Balacci, Sergiu; Osipciuc, Galina; Furdui, Vlada; Harea, Vasile; Cretu, Roman; Bacu, Gheorghe; Țurcanu, Parascovia; Temciuc, Vlad; Filippov, Artiom
Spermatogenesis is a continuous process, maintained by the self-renewal and differentiation of spermatogonial stem cells (SSC), which arise from undifferentiated precursors (gonocytes) in the physiological conditions of the testicular cell niche. SSC serve as the foundation for the physiology of continuous spermatogenesis, they have the ability to self-renew by differentiation to produce spermatozoa suitable for fertilization, therefore the knowledge of the regulatory processes of SSC is of great importance for understanding the fundamental molecular mechanisms of the function of these cells in spermatogenesis. By strict physiological regulation, spermatogonial transitions occur with a complete non-exploitation of equivalent changes in metabolism, a conserved overregulation of mitochondrial function, biogenesis and oxidative phosphorylation in spermatogony differentiation, as well as the relationship between metabolism and the external microenvironment. In the present paper we have tried to review the current state of research in CSS physiology and biology, as well as their molecular regulation, in the physiological and metabolic niches, necessary for fundamental investigations and possible practical applications. Elucidation of the exact mechanisms and characteristics of testicular maturation events and gonocyte transition to SSC by activation of CSS-specific pathways or early embryonic establishment of transcriptional profiling of neonatal and prepubertal spermatogonia will contribute to new achievements of biological, physiological and metabolic aspects of SSC. Increased knowledge regarding the biology, physiology and metabolism of SSC will improve our understanding of the possibilities of applying SSC tools and manipulations in the evolution of spermatogenesis mechanisms.
The relationship of the intestinal microflora and reproductive health (Review)
(Editura USM, 2024) Furdui, Vlada; Ciobanu, Elena; Leorda, Ana; Balan, Ion
În prezent, există o creștere pe scară largă a interesului pentru microflora intestinală și impactul acesteia asupra sănătății și bolilor umane. Acest articol prezintă sinteză narativă privind interrelația dintre microbiomul intestinal și sănătatea reproductivă. Sunt studiate atât patologiile sistemului de reproducere feminin asociate cu disbioza intestinală, cât și relația dintre microbiota intestinală și funcția de reproducere a bărbaților. Cercetările viitoare ar trebui să se orienteze pe identificarea mecanismelor moleculare care stau la baza relației cauzale dintre microbiota intestinală și sănătatea reproducerii.
RELEVANȚA BIOLOGIEI REPRODUCERII ȘI CONSERVĂRII ÎN CONTINUITATEA BIODIVERSITĂȚII
(CEP USM, 2024) Balan, Ion; Drugociu, Dan Gheorghe; Roşca, Nicolae; Balacci, Sergiu; Buzan, Vladimir; Furdui, Vlada; Harea, Vasile; Hanțațuc, Alexei; Moroz, Mihail; Turcanu, Parascovia; Olaru, Iulia
Wild and domestic animal breeding programs, a vital insurance strategy to conserve the biodiversity of endangered species and to facilitate the field of research that offers solutions to many aspects of the biodiversity crisis. Reproduction is a particularly essential component of conservation, where the protection of life remains one of society’s highest priorities. When applying the biology of long-term or short-term preservation of preserved semen, it is necessary to take into account the specific aspects of cryobiology, or sperm dehydration, with the reco very of cellular and nuclear structures, being the major contributors, both to the preservation of biodiversity and How. to the development of reproductive sciences.Currently, advances in the preservation of reproductive cells and the creation of cryogenics of genetic resources offer decisive solutions in the maintenance of biodiversity, and their strategy depends on the amount and duration of storage of frozen semen for several generations to come.
THE ROLE AND IMPORTANCE OF REPRODUCTIVE BIOTECHNOLOGIES IN ANIMAL BIODIVERSITY
(CEP USM, 2022-09-29) Balan, Ion; Roșca, Nicolae; Buzan, Vladimir; Balacci, Sergiu; Cazacova, Iulia; Mereuța, Ion; Crețu, Roman; Bacu, Gheorghe
Sănătatea societății contemporane – problemă globală ce amenință viitorul civilizației. Rezolvarea problemei sănătății e posibilă doar prin dezvoltarea sanocreatologiei
(Editura USM, 2024) Furdui, Teodor; Ciochină, Valentina; Furdui, Vlada; Vudu, Stela; Priseajniuc, Victoria; Glijin, Aliona; Balan, Ion; Vrabie, Valeria; Jitari, Iurii
The paper examines the problem of somato-vegetative health of the contemporary population as one of the most important, which determines the future of civilization. The analysis of the bibliographic literature indicates the insufficient study of the systems and mechanisms that determine the formation,maintenance and deterioration of health, as a specific phenomenon that ensures the human vitality and daily activity. Based on the literature and special own studies, the definition of somatovegetative health, physiological and psychical indicators of health identification, determinants of the formation and deterioration of health were developed and argued. Evidence is provided in support of the statement of the way to solve the health problem - the development of sanocreatology, science about creating,maintaining, strengthening health of the human organism and preventing its premature deterioration.
STIMULAREA SPERMATOGENEZEI LA COCOŞII REPRODUCĂTORI
(2012-09-27) Boronciuc, Gheorghe; Gulea, Aurelian; Țurcanu, Ștefan; Roșca, Nicolae; Balan, Ion; Varmari, Nina; Bârcă, Maria; Didilica, Ina
The purpose of research was a development of a method of stimulation spermatogenesis at cocks which will provide quantitative and qualitative increase in indicators of sperm. By means of physiological methods was established that the drug LAZ promotes increase spermatogenesis at cocks. It was used by an oral way in a dose of 1 ml on an individual of cock, within 5 weeks. An active component of a coordinative drug with stimulating property is easily assimilated.