Browsing by Author "Andronache, L. M."

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    IN VITRO ANTIPROLIFERATIVE POTENTIAL AND ANTIOXIDANT CAPACITY OF NEW COORDINATION COMPOUNDS
    (Marina Sokolova Publishings, 2017) Garbuz, O.S.; Graur, V.O.; Tagadiuc, O.C.; Andronache, L. M.; Sradari, V.V.; Gulea, A.P.; Gudumac, V.S.
    In the present study the ability of coordination compounds TIA - 90, TIA - 91 and TIA - 93 to induce the inhibition of proliferation in the epithelial ce lls of pancreatic carcinoma of the BxPc - 3 line were investigated. Their cytotoxicity against normal kidney epithelial cells of Madin Darby dog's MDCK line was also evaluated. The viability of cancer cells was determined by the Alamar Blue test using the re dox indicator of resazurin. To identify the antioxidant properties of TIA - 90, TIA - 91 and TIA - 93 anticancer agents, we used a relatively simple but reliable ABTS method. Obtained results showed that the compounds TIA - 90 and TIA - 93 have greet antiproliferati ve and antioxidant potentials. The cytotoxic activity of these compounds against normal cells of the MDCK line is lower than that on tumor cells, which indicates the prospect of their use as antitumor agents. However, additional studies are need to evaluate the mechanisms of action of these compounds, as well as their possible adverse effects in other bioassay systems and animal models