Browsing by Author "Думбрава, Влада-Татьяна"

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    ИЗМЕНЕНИЕ СОДЕРЖАНИЯ НЕКОТОРЫХ НЕЙРОМЕДИАТОРНЫХ АМИНОКИСЛОТ У ПАЦИЕНТОВ С ХРОНИЧЕСКИМИ ГЕПАТОПАТИЯМ
    (CEP USM, 2024) Березовская, Елена; Лупашко, Юлианна; Думбрава, Влада-Татьяна; Постолати, Галина
    Glycine, Gamma-aminobutyric acid (GABA), Glutamate, and Aspartate are neurotransmitter amino acids. It was examined 24 patients with chronic hepatopathy: 12 patients with chronic HBV infection (group I) and 12 patients with hepatic steatosis (group II), the control group (CG) consisted of 12 practically healthy individuals. Quantitative determination of Aspartate, Glutamate, Glycine and GABA in blood serum was carried out using liquid chromatography. In I-st group of patients the level of Glycine was 18.76±1.45, GABA - 0.83±0.06, Aspartate – 5.56±0.97, and Glutamate – 6.34±0.70 mcM/dL. In II-nd group: the level of Glycine was 22.37±0.91, GABA - 0.77±0.03, Aspartate – 5.16±0.74, and Glutamate – 7.87±1.47 mcM/dL. In CG: the level of Glycine y was 22.93±2.21, GABA – 0.55±0.06, Aspartate – 2.69±0.45, and Glutamate – 12.46±1.92 mcM/dL. A violation of neurotransmitter amino acids metabolism is found in chronic hepatopathy. A decrease in glycine and glutamate was observed in patient’s blood serum, with an increase in GABA and aspartate. These disorders are most profound in individuals with chronic viral infection B.
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    ИСПОЛЬЗОВАНИЕ ПСИХОМЕТРИЧЕСКИХ МЕТОДОВ ДЛЯ ДИАГНОСТИКИ ЭМОЦИОНАЛЬНОГО СТАТУСА У ПАЦИЕНТОВ С ХРОНИЧЕСКИМИ ГЕПАТОПАТИЯМИ
    (CEP USM, 2021-04-22) Березовская, Елена; Думбрава, Влада-Татьяна
    The article presents a theoretical analysis of scientific literature on the co-morbidity of depression and chronic hepatopathy. It highlights the problem of growing prevalence of liver pathology in both Republic of Moldova and worldwide. A systematization attempt of published psychometric and clinical methods for diagnosing depressive disorders in patients with chronic hepatopathy has been carried out as well as an elaboration of a possible way of classification of the methods examined. An algorithm has been created for applying a certain technique, depending on goals and possibilities of study of depression in patients with chronic hepatopathy. The article stresses the need for a systematic methodologically justified approach to the diagnosis of depressive disorders of the patients.