Browsing by Author "Țurcanu, Parascovia"

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    Proprietățile celulelor stem spermatogoniale în mediul nișelor fiziologice și metabolice testiculare
    (Editura USM, 2024) Balan, Ion; Gavojdian, Dinu; Budevici, Alexandr; Roșca, Nicolae; Buzan, Vladimir; Balacci, Sergiu; Osipciuc, Galina; Furdui, Vlada; Harea, Vasile; Cretu, Roman; Bacu, Gheorghe; Țurcanu, Parascovia; Temciuc, Vlad; Filippov, Artiom
    Spermatogenesis is a continuous process, maintained by the self-renewal and differentiation of spermatogonial stem cells (SSC), which arise from undifferentiated precursors (gonocytes) in the physiological conditions of the testicular cell niche. SSC serve as the foundation for the physiology of continuous spermatogenesis, they have the ability to self-renew by differentiation to produce spermatozoa suitable for fertilization, therefore the knowledge of the regulatory processes of SSC is of great importance for understanding the fundamental molecular mechanisms of the function of these cells in spermatogenesis. By strict physiological regulation, spermatogonial transitions occur with a complete non-exploitation of equivalent changes in metabolism, a conserved overregulation of mitochondrial function, biogenesis and oxidative phosphorylation in spermatogony differentiation, as well as the relationship between metabolism and the external microenvironment. In the present paper we have tried to review the current state of research in CSS physiology and biology, as well as their molecular regulation, in the physiological and metabolic niches, necessary for fundamental investigations and possible practical applications. Elucidation of the exact mechanisms and characteristics of testicular maturation events and gonocyte transition to SSC by activation of CSS-specific pathways or early embryonic establishment of transcriptional profiling of neonatal and prepubertal spermatogonia will contribute to new achievements of biological, physiological and metabolic aspects of SSC. Increased knowledge regarding the biology, physiology and metabolism of SSC will improve our understanding of the possibilities of applying SSC tools and manipulations in the evolution of spermatogenesis mechanisms.
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    Relevanța biologiei reproducerii și conservării în continuitatea biodiversității [Articol]
    (CEP USM, 2024) Balan, Ion; Drugociu, Dan Gheorghe; Roşca, Nicolae; Balacci, Sergiu; Buzan, Vladimir; Furdui, Vlada; Harea, Vasile; Hanțațuc, Alexei; Moroz, Mihail; Țurcanu, Parascovia; Olaru, Iulia
    Wild and domestic animal breeding programs, a vital insurance strategy to conserve the biodiversity of endangered species and to facilitate the field of research that offers solutions to many aspects of the biodiversity crisis. Reproduction is a particularly essential component of conservation, where the protection of life remains one of society’s highest priorities. When applying the biology of long-term or short-term preservation of preserved semen, it is necessary to take into account the specific aspects of cryobiology, or sperm dehydration, with the recovery of cellular and nuclear structures, being the major contributors, both to the preservation of biodiversity and How. to the development of reproductive sciences. Currently, advances in the preservation of reproductive cells and the creation of cryogenics of genetic resources offer decisive solutions in the maintenance of biodiversity, and their strategy depends on the amount and duration of storage of frozen semen for several generations to come.