Browsing by Author "Șeptițchi, Vladimir"

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ABORDĂRI MODERNE PRIVIND DINAMISMUL MORFOFUNCŢIONAL AL PROCESULUI DE SPERMATOGENEZĂ
(CEP USM, 2023) Șeptițchi, Vladimir; Leorda, Ana; Raischi, Viorica; Grosul-Raileanu, Olesea
Lucrarea rezumă abordările moderne despre dinamismul morfofuncțional al spermatogenezei ca proces dinamic complex cu evenimente celulare și moleculare bine organizate, care include trei etape funcționale specifice de bază‒ spermatocitogeneza (mitoza), meioza și spermiogeneza (diferențierea fără diviziune), și duce la formarea spermatozoizilor. Prima etapă presupune diferențierea spermatogoniilor (celule germinale diploide mici) prin diviziunea mitotică în spermatocite primare. A doua etapă necesită meioză, în care celulele diploide ‒ spermatocitele formează spermatide haploide rotunde. Etapa finală a spermatogenezei implică producerea de spermatozoizi maturi și mobili din spermatide rotunde, printr-un proces numit spermiogeneză. În oricare dintre aceste etape pot apărea tulburări funcționale, ceea ce poate duce la perturbarea întregului proces și la infertilitate. Până în prezent, o înțelegere cuprinzătoare a biologiei celulare și a geneticii spermatogenezei este dificilă, deoarece are loc într-un mediu testicular complex, caracterizat printr-o asociere strânsă a spermatozoizilor în curs de dezvoltare cu celulele suplimentare. Prin urmare, este necesar de a intensifica studiul mecanismelor dinamismului morfofuncțional al spermatogenezei și al reglării acesteia în general și la diferite etape.
ACTIVITY OF DIGESTIVE ENZYMES OF THE SMALL INTESTINE OF RATS WITH DIFFERENT CONSTITUTIONAL STRESS REACTIVITY
(CEP USM, 2022-09-29) Grosul-Raileanu, Olesea; Șeptițchi, Vladimir
CONCEPT, PREVALENCE, DEVELOPMENT TRENDS, AND PSYCHOPHYSIOLOGICAL ASPECTS OF INFO-DIGITAL ADDICTION
(Editura USM, 2024) Grințenco, Ella; Șeptițchi, Vladimir; Borshev, Yuri
The aim of this work is to analyze current sources of scientific literature on the prevalence, key development and growth trends of Info-Digital Addiction (IDA), and its psychophysiological aspects. Modern development trends, primary psychophysiological consequences, prevalence, and main research problems of IDA have been identified. An attempt has been made to introduce a new integrated concept (a generalizing term) of "Info-Digital Addiction." A significant lack of objective statistical data on IDA in the Republic of Moldova has been revealed, highlighting the need to study and monitor the trends and factors of its development among the country's population. Only a comprehensive approach and interdisciplinary cooperation will allow for a complete understanding of the problem's scale and the development of effective prevention and treatment strategies for IDA.
CONDITIONED REFLEX LEARNING AND MEMORY OF WHITE RATS OF DIFFERENT AGES UNDER THE INFLUENCE OF THE BIOMASS OF STREPTOMYCETES ISOLATED FROM THE SOILS OF THE REPUBLIC OF MOLDOVA
(CEP USM, 2022-09-29) Garbuzneac, Anastasia; Șeptițchi, Vladimir
MEMBRANE HYDROLYSIS OF MALTOSE IN THE SMALL INTESTINE UNDER THE INFLUENCE OF DIETS WITH DIFFERENT CONTENT OF CARBOHYDRATES IN EARLY POSTNATAL ONTOGENESIS
(CEP USM, 2022-09-29) Mangul, Olga; Șeptițchi, Vladimir
MODIFICĂRILE CANTITATIVE ȘI CALITATIVE ALE MICROBIOTEI INTESTINALE CA PREDICTOR PRECOCE AL CANCERULUI COLORECTAL
(CEP USM, 2024) Leorda, Ana; Șeptițchi, Vladimir; Tolstenco, Dorina
As a pressing global health problem, colorectal cancer (CRC) requires effective therapeutic strategies, and the underlying mechanisms remain an essential subject of investigation in this field. The problem of identifying some predictive markers of the probability of the appearance of this type of malignant neoplasms is quite current. Disturbance of the normal community of intes tinal bacteria represents an important problem in the development of CRC, thus new predictive markers of the probability of the appearance of this type of malignant neoplasms can be identi fied in changes in the qualitative and quantitative composition of the intestinal microbiota (MI). The subsequent development of preparations based on previously identified indigenous medicinal plants, which on the one hand have an anti-cancer effect, and on the other hand possess prebiotic properties, stimulate the multiplication of normal intestinal microbial flora. Targeted formation and maintenance of normal intestinal microbiota will be the basis for the development of new strategies in the prevention and treatment of CRC.
PARTICULARITĂȚILE HIDROLIZEI MEMBRANARE ȘI A ABSORBȚIEI GLUCIDELOR ÎN INTESTINUL SUBȚIRE LA ȘOBOLANII ALBI ÎN FUNCȚIE DE STRESOREACTIVITATEA CONSTITUȚIONALĂ
(Editura USM, 2024) Grosul-Raileanu, Olesea; Șeptițchi, Vladimir; Leorda, Ana
The aim of this work is to clarify the features of membrane hydrolysis of maltose and the absorption of glucose formed during hydrolysis, as well as free glucose and fructose in the small intestine of rats with different levels of constitutional stress reactivity. Significant differences in the intensity of free glucose and fructose absorption, membrane hydrolysis of maltose and absorption of glucose formed during hydrolysis were found in rats with different levels of constitutional stress reactivity. The highest rate of free glucose absorption is observed in animals with an average level of stress reactivity, and fructose - in animals with a low level of reactivity; the lowest rate of free monosaccharide absorption is observed in animals with high stress reactivity. Animals with an average level of constitutional reactivity have a higher intensity of membrane hydrolysis of maltose and glucose formed during hydrolysis compared to animals with high stress reactivity. The obtained data indicate the existence of a connection between the genetically determined stress reactivity of the body and the digestive-transport function of the small intestine.