Pahonțu, ElenaIlieș, Diana CarolinaȘova, SergiuOprean, CameliaPăunescu, VirgilOlaru, Octavian TudorelRădulescu, Flavian ȘtefanGulea, AurelianRoșu, TudorDrăgănescu, Doina2023-10-262023-10-262017PAHONȚU, Elena, ILIEȘ, Diana Carolina, ȘOVA, Sergiu, OPREAN, Camelia, PĂUNESCU, Virgil, OLARU, Octavian Tudorel, RĂDULESCU, Flavian Ştefan, GULEA, Aurelian, ROȘU, Tudor, DRĂGĂNESCU, Doina. Synthesis, characterization, antimicrobial and antiproliferative activity evaluation of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) complexes with isoniazid-derived compound. În: Molecules, 2017, vol. 22, pp. 1-17. ISSN 1420-30491420-3049https://msuir.usm.md/handle/123456789/11476https://doi.org/10.3390/molecules22040650Hydrazone complexes of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) with N-isonicotinoyl-N′-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as IR (infrared), 1H-NMR and 13C-NMR (hydrogen and carbon nuclear magnetic resonance, UV-Vis (ultraviolet-visible), FAB (fast atom bombardment), EPR (electron paramagnetic resonance), and mass spectroscopies. The crystal structure of ligand was determined by single crystal X-ray diffraction studies. Spectral data showed that hydrazone behaves as an ONO tridentate ligand through the azomethine nitrogen, phenolate and keto oxygen atoms. For the copper(II) complexes, metal-ligand bonding parameters were evaluated from the EPR spectra. These parameters indicate the presence of in-plane π bonding. In addition, the f values of complexes 1-4 indicate small distortion from planarity. The effect of these complexes on proliferation of human breast cancer (MCF-7 and SKBR-3), human melanoma (A375), lung adenocarcinoma cells (NCI-H1573) and their antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Candida albicans strains were studied and compared with those of free ligand. The ligand and complexes 1-3 showed significant antimicrobial activity against the Gram-positive bacteria Staphylococcus aureus and Candida albicans in comparison to the control drugs. The complexes 2-4 could be potential antitumor agents, leading to a significant improvement of the cytotoxic activity when compared with HL.encopper(II)cobalt(II)zinc(II)nickel(II) and platinum(II) complexesantimicrobial activityhuman breast SKBR-3 and MCF-7human melanoma A375lung adenocarcinoma cell NCI-H1573Article