Pahonțu, ElenaGulea, AurelianPoirier, D.Tsapkov, V. I.2016-04-052016-04-052014PAHONȚU, E., GULEA. A., POIRIER, D., TSAPKOV, V. Coordination compounds of cobalt, nickel, copper, and zinc with n1 ,n2 -bis(pyridin-2-ylmethylidene)benzene-1,2-diamine and its derivatives. In : Russian Journal of General Chemistry. 2014, Vol. 84, No. 9, pp. 1767-17701070-3632https://msuir.usm.md/handle/123456789/583http://link.springer.com/journal/11176/84/9/page/2о-Phenylenediamine reacts with 2-formyl-, 2-acetyl-, or 2-benzoylpyridine in ethanol in the presence of cobalt, nickel, copper, or zinc chlorides to form monomeric complexes ML1−3 Сl2·nH2O {M = Co, Ni, Cu, Zn; L1 = N1,N2 -bis(pyridin-2-ymethylidene)benzene-1,2-diamine, L2 = N1,N2-bis(pyridin-2-ylethylidene)benzene-1,2-diamine, L3 = N1,N2 -bis[phenyl(pyridin-2-yl)methylidene]benzene-1,2-diamine; n = 0–3}. The condensation products (L1−L3) act in the complexes as tetradentate N,N,N,N-ligands. Thermolysis of thecomplexes occurs in two stages: dehydration (70–95°С) and complete degradation (320–450°С). At concentrations of 10–5–10–7 M, the complexes inhibit in vitro growth and proliferation of HL-60 human promyelocytic leukemia cells.encoordination compoundsazomethinesanticancer activityArticle