Garbuz, OlgaToderas, IonUlchina, IaninaGraur, VasileRailean, NadejdaGulea, Аurelian2023-10-032023-10-032021GARBUZ, Olga, TODERASH, Ion, ULCHINA, Ianina, GRAUR, Vasilii О., RAILYAN, Nadejda, GULYA, A.. The Antiproliferative, Antioxidant Activities and Toxicity of Mixed-Ligand Amine-Containing Copper (II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(Prop-2-En-1-Yl) Hydrazinecarbothioamide. In: Sustainable use and protection of animal world in the context of climate change: dedicated to the 75th anniversary from the creation of the first research subdivisions and 60th from the foundation of the Institute of Zoology, Ed. 10, 16-17 septembrie 2021, Chișinău. Chișinău: Institutul de Zoologie, 2021, Ediția 10, pp. 123-129. ISBN 978-9975-157-82-7. DOI: 10.53937/icz10.2021.20978-9975-157-82-7https://doi.org/10.53937/icz10.2021.20https://msuir.usm.md/handle/123456789/11106Five compounds 2-(2-Hydroxybenzylidene)-N-(prop-2-en1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl) phenolato-S,N,O:O] diaquadicopper (II) nitrate (1), bis [μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl)phenolato-S,N,O:O]d iimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper(II) nitrate hexahydrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl) phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds towards cancer cell lines HeLa, RD and normal cell line MDCK have been investigated. The tested compounds demonstrated high antioxidant and antiproliferative, selective activities towards cancer cells. Direct toxic evaluation of compounds was performed by Daphnia magna bioassay.enArticle