Gulea, AurelianTsapkov, VictorGraur, VasiliiPantea, ValerianaAndronache, LiliaShvets, I.Matusovsky, V.Lisii, D.Botnaru, M.Gudumac, Valentin2022-03-242022-03-242022ANDRONAKE, L., GULEA, A., TSAPKOV, V., et al. Copper(II) coordination compounds with thiosemicarbazide derivatives as inhibitors of superoxide radicals. In: In: Международный научно-исследовательский журнал. 2022, nr. 1 (115), Часть 2. ISSN 2227-6017 (ONLINE), ISSN 2303-9868 (PRINT).2227-6017https://research-journal.org/wp-content/uploads/2022/01/1-115-2.pdf#page=60https://msuir.usm.md/handle/123456789/5891New biologically active coordination compounds of copper(II) based on substituted 3-(phenyl)-1-(pyridin-2-yl)prop-2-en- 1-one 4-allylthiosemicarbazones have been obtained. It was found that these compounds exhibit strong antiradical properties when interacting with a superoxide radical. Due to this property, the obtained compounds can find wide application in medicine as inhibitors of superoxide radicals in the human body, thus preventing damage of cells and tissues, multifactorial diseases, including carcinogenesis. The synthesized coordination compounds expand the arsenal of superoxide radical inhibitors with high biological activity. Their possible significance for the development of new treatment strategies for diseases associated with the overproduction of superoxide radicals discussed.New biologically active coordination compounds of copper(II) based on substituted 3-(phenyl)-1-(pyridin-2-yl)prop-2-en- 1-one 4-allylthiosemicarbazones have been obtained. It was found that these compounds exhibit strong antiradical properties when interacting with a superoxide radical. Due to this property, the obtained compounds can find wide application in medicine as inhibitors of superoxide radicals in the human body, thus preventing damage of cells and tissues, multifactorial diseases, including carcinogenesis. The synthesized coordination compounds expand the arsenal of superoxide radical inhibitors with high biological activity. Their possible significance for the development of new treatment strategies for diseases associated with the overproduction of superoxide radicals discussed.ensuperoxide radical inhibitorscoordination compoundsthiosemicarbazonesингибиторы супероксид-радикаловкоординационное соединениетиосемикарбазоныArticle