Gulea, AurelianUsataia, IrinaGraur, VasiliiCiumacov, IuriePetrenko, PeterBalan, GretaBurduniuc, OlgaȚapcov, VictorRudic, Valeriu2023-10-272023-10-272020GULEA, Aurelian, USATAIA, Irina, GRAUR, Vasilii , CIUMACOV, Iurie, PETRENKO, Peter , BALAN, Greta, BURDUNIUC, Olga, ȚAPCOV, Victor , RUDIC, Valeriu. Synthesis, Structure and Biological Activity of Coordination Compounds of Copper, Nickel, Cobalt, and Iron with Ethyl N'-(2-Hydroxybenzylidene)-N-prop-2-en-1-ylcarbamohydrazonothioate.În: Russian Journal of General Chemistry, 2020, vol. 90, pp. 630-639. ISSN 1070-36321070-3632https://msuir.usm.md/handle/123456789/11484https://doi.org/10.1134/S107036322004012XN-(Prop-2-en-1-yl)hydrazonocarbothioamide reacts with iodoethane in methanol with further addition of 2-hydroxybenzaldehyde to form hydroiodide of carbamohydrazonothioate (HL·HI). The coordination compounds were obtained by interaction of HL or HL·HI with copper, nickel, cobalt and iron salts CuLХ·nH2O [X = Cl–, Br–, NO3–; n = 0–1], Ni(L)2·HI·CH3OH, Сo(L)2X [X = I–, NO3–] and Fe(L)2NO3. The structures of three complexes were established by single crystal X-ray analysis. The synthesized complexes exhibit selective antimicrobial and antifungal activity against a series of standard microorganisms and fungi in the concentration range of 30–500 μg/mL. In addition, nickel and iron complexes selectively inhibit the growth and proliferation of cancer cells and do not adversely affect normal cells.encoordination compoundscarbamohydrazonothioatesantimicrobial activityanticancer activityArticle