Boldescu, VeaceslavKacso, IrinaBratu, IoanDuca, Gheorghe2018-03-262018-03-262008BOLDESCU, V., KACSO, I., et al. In: Cemistry Journal of Moldova. 2008, nr.1, pp. 85-88. ISSN 1857-1727.1857-1727https://msuir.usm.md/handle/123456789/1716The main aim of this study was to investigate the infl uence of pH and the presence of hydrophilic polymer polyvinylpyrrolidone on the formation of sanguinarine-β-cyclodextrin (SANG-β-CD) inclusion complex. Spectrophotometric studies of the SANG-β-CD systems in the presence and without 0.1 % PVP at the pH 5.0 did not show any evidence of the complex formation. However, the same systems showed several obvious evidences at the pH 8.0: the hyperchromic and the hypochromic effects and the presence of the isosbestic point in the region of 200 – 210 nm. The association constants calculated by three linear methods: Benesi-Hildebrand, Scott and Scatchard, were two times higher for the systems with addition of 0.1% PVP than for the systems without it.ensanguinarineβ -cyclodextrininclusion complexUV-vis spectrophotometryassociation constantArticle