Rusnac, R.Petrenco, P.Chumakov, Yu.Botnaru, MariaGulea, Aurelian2019-04-102019-04-102018RUSNAC, R.., PETRENCO,P. et al. Structure of 2-[-3-(4-methylphenyl)-1-(pyridin-2-YL)prop-2-en-1-ylidene]hydrazine-1-carbothioamide. In: Conferința "International Conference on Materials Science and Condensed Matter Physics", Chișinău, Moldova, 25-28 septembrie 2018. Ch.: 2018, p.130.https://msuir.usm.md/handle/123456789/2019During the recent years, a large number of chalcone-derived thiosemicarbazones are found to have potential therapeutic applications. They possess diverse biological activities including anti-inflammatory, antimicrobial and as cell growth inhibitor. It was found that the biological properties of these complexes correlate with their structures and the metal coordination leads to an improvement of chalcone-thiosemicarbazones pharmacological activities and synergistic effects. The aim of this work is the synthesis and the determination of structural and biological properties of 2-[-3-(4-methylphenyl)-1-(pyridin-2-yl)prop-2-en-1-ylidene]hydrazine-1-carbothioamide (I). In C=N-NH-CS backbone of I the S atom is in trans to azomethine N atom. This core of the studied ligand is essentially planar within 0.01 Ǻ. In I the dihedral angles of aromatic rings with mentioned backbone are equal to 30.0 and 32.2° respectively. In the crystal the molecules form the centro symmetric dimers via N-HS hydrogen bonds which in turn join through the N-H…N H-bonds. The synthesized compound I shows the moderate inhibition of HeLa, BxPC-3, TC-1 cancer cells in the range of concertation of 10-1 μM.othercancer cellsinhibitor.Article