Robu, ȘtefanPotlog, TamaraBulimestru, IonLungu, IonSadohina, OlgaDruța, AlexandrinaBulmaga, PetruGuțu, Iacob2025-08-152025ROBU, Ștefan; Tamara POTLOG; Ion BULIMESTRU; Ion LUNGU; Olga SADOHINA; Alexandrina DRUȚĂ; Petru BULMAGA and Iacob GUŢU. Synthesis of chitosan grafted with aminomethyl zinc phthalocyanine for photodynamic therapy. Chemistry journal of Moldova: General, Industrial and Ecological Chemistry. 2025, nr.1 (20), pp.62-68. ISSN (p) 1857-1727; ISSN (e) 2345-1688. Disponibil: https://doi.org/10.19261/cjm.2025.12171857-17272345-1688https://msuir.usm.md/handle/123456789/18520https://doi.org/10.19261/cjm.2025.1217This paper reports the synthesis of a substituted aminomethyl zinc phthalocyanine (AmPcZn) and its covalent grafting onto chitosan via an ethyl chloroformate-mediated reaction. Chitosan-based copolymers containing 10%, 20%, 30%, and 60% (w/w) AmPcZn were successfully obtained. The chemical structure of the synthesized AmPcZn was confirmed by 1H-NMR spectroscopy and elemental analysis, which were consistent with the expected molecular composition. The grafting reaction and structural integrity of the resulting copolymers were investigated using Fourier-transform infrared (FTIR) and UV-Vis spectroscopies. FTIR spectra revealed characteristic amide and carbonyl stretching bands, confirming covalent bond formation between chitosan and AmPcZn. UV-Vis measurements showed a concentration-dependent increase in absorbance and a typical splitting of the Q-band with band at 605 nm and 715 nm, indicating the successful incorporation of the phthalocyanine moiety into the polymeric matrix.enZnPc derivativechitosangrafting reactionUV-Vis spectroscopyFTIR spectroscopyArticle