Browsing by Author "Tsapkov, Victor I."
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Item COORDINATION COMPOUNDS OF COBALT, NICKEL, AND COPPER OF SOME 1,3-DIPHENYLPYRAZOLE-4-CARBALDEHYDE THIOSEMICARBAZONES(Academia de Ştiinţe a Moldovei, 2015) Gulea, Aurelian; Tsapkov, Victor I.; Cotovaia, Aliona; Garbuz, Olga; Graur, Vasilii О.; Nicolenco, Aliona; Guţu, Iacob; Gudumac, ValentinItem THE CRYSTAL STRUCTURE AND ANTIMICROBIAL ACTIVITY OF BIS[METHYLN ’ -(2-HYDROXOBENZYLIDENE)-N-PROP-2-EN-1- YLCARBAMOHYDRAZONOTHIOATE]CHROMIUM(III) NITRATE(Academia de Ştiinţe a Moldovei, 2015) Petrenko, Peter A.; Graur, Vasilii О.; Chumakov, Yurii; Truhina, Irina; Tsapkov, Victor I.; Prisakari, Viorel I.; Zariciuc, Elena; Rudic, Valeriu; Gulea, AurelianItem THE CRYSTAL STRUCTURE AND ANTITUMOR ACTIVITY OF 1,6-DINITRATO-BIS[2-(5-METHYLSULFANYL)-4-(PROP-2-EN-1-YL)-4- -(1,2,4-TRIAZOL-3-YL)PYRIDINE]COPPER(Academia de Ştiinţe a Moldovei, 2015) Petrenko, Peter A.; Graur, Vasilii О.; Chumakov, Yurii; Truhina, Irina; Tsapkov, Victor I.; Poirier, Donald; Gulea, AurelianItem THE CRYSTAL STRUCTURES AND ANTITUMOR ACTIVITY OF 1-PHENYL3-METHYL-4-BENZOYL-5-PYRAZOLONE 4-ETHYLTHIOSEMICARBAZONE AND ITS COPPER(II) COMPLEXES(Academia de Ştiinţe a Moldovei, 2012) Gulea, Aurelian; Julea, Felicia; Tsapkov, Victor I.; Chumakov Yurii; Petrenko Peter A.; Sofroni, Larisa; Stefan-van Staden, Raluca-IoanaItem CRYSTAL STRUCTURES OF COPPER (II) COMPLEXES WITH 5-CHLORINE- AND 5-BROMINE-SUBSTITUTED N-ETHANOLSALICYLIDENIMINES(Academia de Ştiinţe a Moldovei, 2006) Chumakov, Yurii; Tsapkov, Victor I.; Bocelli, Gabriele; Antosyak, B.; Gulea, AurelianThe condensation products of alcanolimines with aldehydes and ketons form the biologically active coordination compounds with ions of transition metals differing in composition, structure and properties. In this respect, the synthesis of biometal complexes with similar ligands and investigations of the structural features of these compounds are of great interest from scientific and practical standpoints. Therefore the crystal structures of bis-{4-bromo-2-[(2-hydroxy-ethylamine)methyl]phenole}copper (I), bis-{4-chloro-2-[(2-hydroxy-ethylamine)-methyl]phenole}copper (II) have been studied. Crystals of I are monoclinic, a = 13.237(3), b = 4.589(1), c = 21.010(4) Å, space group P21/c, Z =2, R = 0.036. Crystals of II are also monoclinic, a = 4.994 (1), b = 17.034 (3), c = 10.723 (2) Å, space group P21/n, Z =2, R = 0.066. In I and II the metal atom is situated at symmetry center. In I the copper atom coordinates two singly deprotonated bidentate molecules of 4-bromo-2-[(2-hydroxy-ethylamine)-methyl]phenol through the phenolic oxygen atoms and azomethine nitrogen atoms. The donor atoms form the distortion square around the central atom due to center of symmetry. In II the copper atom coordinates two singly deprotonated bidentate molecules of 4-chloro-2-[(2-hydroxy-ethylamine)-methyl]phenol through the phenolic oxygen atoms and azomethine nitrogen atoms. The coordination polyhedron of the central atom is an extended tetragonal bipyramid with the phenolic oxygen atoms and azomethine nitrogen atoms in its base. Both axial vertexes of bipyramid are occupied by the oxygen atoms of aminealcohol groups of adjacent complexes connected with the initial complex by symmetry center. In turn the oxygen atoms of amine alcohol groups of initial complex are located in coordination bipyramid apexes of neighboring complexes and thus forming the infinite polymeric chains along a axis.Item THE CRYSTAL STRUCTURES OF IMIDAZOLE-[2-(2-HYDROXО-BENZYLIDENE)- N-(PROP-2-EN-1 YL)HYDRAZINCARBOTHIOAMIDE]-COPPER(II) AND (3,5- DIBROMOPYRIDINE)-[2-(2-HYDROXОBENZYLIDENE)-N-(PROP-2-EN-1- YL)HYDRAZINECARBOTHIOAMIDE]COPPER(II) NITRATES(Academia de Ştiinţe a Moldovei, 2015) Petrenko, Peter A.; Graur, Vasilii О.; Chumakov, Yurii; Smaglii, Vadim; Tsapkov, Victor I.; Crudu, Valeriu; Eftodii, Sergiu; Gulea, AurelianItem CRYSTAL STRUCTURES OF NITRATO-COPPER(II) COMPLEXES COMPRISING 4,4’ -BIPYRIDYL AND SALICYLIDEN- OR NAPHTHALIDENAMINOETHANOL(Academia de Ştiinţe a Moldovei, 2006) Chumakov, Yurii; Petrenko, Peter A.; Tsapkov, Victor I.; Bocelli, Gabriele; Gulea, AurelianCopper (II) nitrate with 2-[2-(hydroxyethylimino)-methyl]-phenol (H2L), 2-[2(hydroxyethylimino)-methyl]-naphtol (H2L1) and heterocyclic amines has been found to generate polynuclear coordination compounds with antimicrobial properties. It was established that polynuclear complexes are formed depending on the nature of the proton-accepting agent, pH and temperature of the reaction mixture. The structure of these compounds, dentate number of the nitrate group, physicochemical properties and antimicrobial activity are determined by the nature of these amines. It was of great interest to study how the replacement of different amines by 4,4’-bipyridyl (Bipy) affects the complex structure. In connection with this, we have synthesized complexes [Cu3(Bipy)3(H2O)2(HL)2(NO3)4]n (I) and [Cu2(Bipy)(HL1)2(NO3)2] (II), where L = 2-[(2-Hydroxy-ethylimino)methyl]-phenol, L1 = 1-[(2-Hydroxyethylimino)methyl]-naphthalen-2-ol, and determined their crystal structures by X-ray diffraction analysis. The crystal structure I consists of polymeric bands [Cu3(Bipy)3(H2O)2(HL)2(NO3)4] along [001] direction. The coordination polyhedra of Cu(1) and of Cu(2) are tetragonal bipyramids. The basic structural unit of II is the binuclear complex [(HL1)(NO3)Cu(Bipy)Cu(NO3)(HL1)] which forms the crystal structure II by means of multiple hydrogen bonds.Item INTRODUCING N-HETEROAROMATIC BASES INTO COPPER(II) THIOSEMICARBAZON COMPLEXES: A WAY TO CHANGE THEIR BIOLOGICAL ACTIVITY(2022) Ulchina, Ianina; Tsapkov, Victor I.; Graur, Vasilii O.; Chumakov, Yurii; Garbuz, Olga; Burduniuc, Olga; Ceban, Emil; Gulea, AurelianThree new copper(II) complexes, [Cu(1,10-Phen)(L)] (1), [Cu(2,2’- Bpy)(L)] (2) and [Cu(3,4-Lut)(L)] (3), where H2L=2-[(2,4- dihydroxyphenyl)methylidene]-N-(prop-2-en-1-yl)hydrazine-1- carbothioamide, 1,10-Phen=1,10-phenanthroline, 2,2’-Bpy= 2,2’-bipyridine, 3,4-Lut=3,4-lutidine, have been synthesized and characterized by elemental analysis, FTIR spectroscopy and single crystal X-ray crystallography (1, 2). All compounds are mononuclear. The introduction of a monodentate N-heteroaromatic base (3,4-dimethylpyridine) has led to a significant increase of antimicrobial activity against Gram-negative Escherichia coli and antifungal activity against Candida albicans compared to the pro-ligand and the precursor complex [Cu- (L)H2O]. The introduction of bidentate N-heteroaromatic bases did not lead to such increase of antimicrobial and antifungal activities. Moreover, complex 3 surpasses the inhibitory activity of tetracycline toward Enterobacter cloacae and the inhibitory activity of fluconazole toward Candida parapsilosis and Cryptococcus neoformans. The study of antioxidant activity against cation radicals ABTS* + showed that complexes 1–3 are more active than Trolox, but only introduction of the monodentate Nheteroaromatic base (3,4-dimethylpyridine) led to the increase of antioxidant properties compared to the precursor complex.Item STUDY OF MAGNETIC AND ANTIOXIDATIVE PROPERTIES OF SOME BIOMETAL COORDINATION COMPOUNDS OF o-VANILLIN ISONICOTINOYLHYDRAZONE(Academia de Ştiinţe a Moldovei, 2015) Gulea, Aurelian; Tsapkov, Victor I.; Bîrcă, Maria; Cotovaia, Aliona; Gudumac, Valentin; Garbuz, Olga; Petcenco, I.; Malic, ElenaItem SYNTHESIS AND BIOLOGICAL ACTIVITY OF COPPER, NICKEL, AND COBALT COORDINATION COMPOUNDS OF CONDENSATION PRODUCTS OF SOME CHALCONES WITH 4-PHENYLTHIOSEMICARBAZIDE(Academia de Ştiinţe a Moldovei, 2015) Tsapkov, Victor I.; Boeva, Maria; Botnaru, Maria; Garbuz, Olga; Gulea, Aurelian; Gudumac, ValentinItem SYNTHESIS, STRUCTURE AND BIOLOGICAL ACTIVITY OF COPPER(II) COMPLEXES WITH 1,3-DIHYDROXY-2-METHYL-2- (SALICYLIDENEAMINO)PROPANE AND SOME OF ITS DERIVATIVES(Academia de Ştiinţe a Moldovei, 2012) Olan, O.; Bulimaga, Valentina; Rudic, Valeriu; Paholco, Chiril; Tsapkov, Victor I.; Gulea, AurelianItem SYNTHESIS, STRUCTURE AND BIOLOGICAL ACTIVITY OF SOME 3D-METAL COMPLEXES OF SOME DERIVATIVES OF SALICYLALDEHYDE 4-ALLYLTHIOSEMICARBAZONES(Academia de Ştiinţe a Moldovei, 2012) Gulea, Aurelian; Graur, Vasilii О.; Zariciuc, Elena; Tsapkov, Victor I.Item SYNTHESIS, STRUCTURE, AND ANTIOXIDANT ACTIVITY OF SOME BIOMETAL COORDINATION COMPOUNDS OF PENTANE-2,4-DIONE BIS-(4-(PYRID-2- YL)THIOSEMICARBAZONE)(Academia de Ştiinţe a Moldovei, 2015) Gulea, Aurelian; Tsapkov, Victor I.; Cotovaia, Aliona; Garbuz, Olga; Anachii, A.; Gudumac, ValentinItem SYNTHESIS, STRUCTURE, AND ANTITUBERCULOUS PROPERTIES OF COPPER COORDINATION COMPOUNDS WITH 2-HYDROXY-3- METHOXYBENZALDEHYDE ISONICOTINOYLHYDRAZONE(Academia de Ştiinţe a Moldovei, 2015) Gulea, Aurelian; Tsapkov, Victor I.; Bîrcă, Maria; Cotovaia, Aliona; Crudu, Valeriu; Eftodii, Sergiu; Malic, ElenaItem SYNTHESIS, STRUCTURE, AND BIOLOGICAL ACTIVITY OF COPPER COORDINATION COMPOUNDS OF SUBSTITUTED PYRIDINE-2-CARBALDEHYDE 4-(o-, m-, p-METHOXYPHENYL)THIOSEMICARBAZONES(Academia de Ştiinţe a Moldovei, 2015) Gulea, Aurelian; Mitkevich, N.; Tsapkov, Victor I.; Garbuz, Olga; Prisakari, Viorel I.