Browsing by Author "Barba, Alic"

Filter results by typing the first few letters
Now showing 1 - 10 of 10
  • Thumbnail Image
    Item
    MAGNETIC STUDY IN SOLUTION OF LANTHANIDE(III)-BISMUTH(III) COORDINATION COMPOUNDS BY MEANS OF NMR SPECTROSCOPY
    (Academia de Ştiinţe a Moldovei, 2012) Gulea, Aurelian; Popa, Nelea; Barba, Alic; Bulimestru, Ion
  • Thumbnail Image
    Item
    ONE - STEP SELECTIVE SYNTHESIS OF 13-EPI-MANOYL OXIDE
    (Institutul de Chimie al AŞM, 2021) Morarescu, Olga; Traistari, Marionela; Barba, Alic; Duca, Gheorghe; Ungur, Nicon; Kulciţki, Veaceslav
    The selective one-step synthesis of 13-epi-manoyl oxide is reported based on a low-temperature superacidic cyclization of sclareol. The reaction conditions have been finely tuned in order to achieve a 9:1 ratio between epimeric oxides in favour of the desired 13-epi-oxide. The structures were confirmed by 1H and 13C NMR, and composition of the crude reaction products determined by GC-MS. These results have been interpreted by a hypothetical SN2 mechanism which occurs with inversion of configuration around the C-13 chiral center of the starting substrate. The preparative value of the elaborated procedure is demonstrated on a gram-scale experiment.
  • Thumbnail Image
    Item
    SYNTHESIS AND ANTILEUKAEMIA ACTIVITY OF N-(2,4-DIMETHYLPHENYL)HYDRAZINE CARBOTHIOAMIDE AND ITS AZOMETHINE DERIVATIVES
    (2012) Gulea, Aurelian; Barba, Alic; Jalbă, Alexandru; Poirier, Donald; Petrenko, Peter A.; Ciumacov, Iurie; Sargun, Artur
    Prezenta lucrare conţine date despre sinteza, caracterizarea şi evaluarea in vitro a activităţii biologice a N-(2,4-dimetilfenil)hidrazinocarbotioamidei şi a cinci derivaţi azometinici ai acesteia, obţinuţi prin condensarea N-(2,4-dimetilfenil)hidrazincarbotioamidei cu diferiţi compuşi carbonilici. Compoziţia şi structura cristalină a compuşilor sintetizaţi a fost determinată cu ajutorul spectroscopiei 1H, 13C RMN şi a difracţiei cu raze X a monocristalelor. Toţi compuşii obţinuţi au fost testaţi ca inhibitori ai proliferării celulelor de leucemie umană HL-60. A fost stabilit că N-(2,4-dimetilfenil)-2-(tiofen- 3-ilmetilen)hidrazinocarbotioamida şi N-(2,4-dimetilfenil)-2-(2-hidroxibenziliden) hidrazinocarbotioamida sunt cei mai activi agenţi antiproliferativi obţinuţi în acest studiu.
  • Thumbnail Image
    Item
    SYNTHESIS AND ANTILEUKAEMIA ACTIVITY OF N-(2,4-DIMETHYLPHENYL)HYDRAZINECARBOTHIOAMIDE AND ITS AZOMETHINE DERVIATIVES
    (Academia de Ştiinţe a Moldovei, 2017) Erhan, Tatiana; Jalba, Svetlana; Sargun, Artur; Barba, Alic; Poirier, Donald; Gulea, Aurelian; Pahontu, Elena
  • Thumbnail Image
    Item
  • Thumbnail Image
    Item
    SYNTHESIS OF HIGHLY FUNCTIONALIZED BIOLOGICALLY ACTIVE TETRACYCLIC DITERPENOIDS FROM ENT-KAUR-16-EN-19-OIC ACID UNDER MODIFIED PRÉVOST-WOODWARD REACTION CONDITIONS
    (2021) Morărescu, Olga; Grinco, Marina; Kulcițki, Veaceslav; Barba, Alic; Garbuz, Olga; Gulea, Aurelian; Ungur, Nikon
    A procedure has been developed for the synthesis of highly functionalized tetracyclic diterpenoids from natural ent-kaur-16-en-19-oic acid under modified Prévost–Woodward reaction conditions. The reaction follows an unusual pathway which leads mainly to bromination or rearrangement products. The transforma­tion of ent-kaur-16-en-19-oic acid afforded a mixture of (16ZE)-17-bromo-ent-kaur-16-en-19-oic, (15R,16E)-17-bromo-15-acetoxy-ent-kaur-16-en-19-oic, (16S)-17-bromo-16-acetoxy-ent-kaur-19-oic, (15S)-15-acetoxy-ent-kaur-16-en-19-oic, and (15S)-15-hydroxy-ent-kaur-16-en-19-oic acids, the latter two being reported previously. The newly syn­thesized compounds were evaluated for their cytotoxicity against two cancer cell lines, HeLa and BxPC-3.
  • Thumbnail Image
    Item
    SYNTHESIS OF NEW HOMODRIMANE SESQUITERPENOIDS CONTAINING DIAZINE, 1,2,4-TRIAZOLE AND CARBAZOLE RINGS
    (2018) Duca, Gheorghe; Aricu, Aculina; Lungu, Lungu; Tenu, Nadejda; Ciocarlan, Alexandru; Gutu, Yacob; Dragalin, Ion; Barba, Alic
    The present paper reports on six step synthesis of 11-homodrim-6,8-dien-12-oic acid N-substituted amides containing diazine, 1,2,4-triazole and carbazole rings based on commercially available sclareolide. The mentioned compounds were prepared for the first time by interaction of the generated in situ acyl chloride with some heterocyclic amines: 2- and 4-aminopyrimidine, 2-aminopyrazine, 5-amino-1,2,4-triazole and N-aminocarbazole. Their structures were fully elucidated by elemental and spectral analyses (IR, 1H and 13C NMR).
  • Thumbnail Image
    Item
    SYNTHESIS OF SOME N’-n-DIMETHYLPHENYL-N,N-DIMETHYLTHIOUREAS WITH ANTIPROLIFERATIVE PROPERTIES
    (Academia de Ştiinţe a Moldovei, 2015) Guţu, Tatiana; Barba, Alic; Prisacaru, Viorel
  • Thumbnail Image
    Item
    SYNTHESIS, STRUCTURE AND IN VITRO ANTIPROLIFERATIVE ACTIVITY OF SOME HYDRAZONES AND THEIR COPPER COMPLEXES
    (2013) Gulea, Aurelian; Paholnițcaia, Anastasia; Barba, Alic; Poirier, Donald
    Lucrarea conţine date despre sinteza, caracterizarea şi evaluarea in vitro a activităţii biologice a hidrazonelor în baza 2-hidrazinobenzotiazolului şi a 4 compuşi complecşi obţinuţi în baza 2-[2-(Piridin-2-ilmetilene)hidrazinil]-benzo[d]tiazolului şi 2-[2-(1-Piridin-2-il) etilidene)hidrazinil] benzo[d] tiazolului dihidrat. Compoziţia compuşilor sintetizaţi a fost determinată cu ajutorul spectroscopiei 1H, 13C RMN. Toţi compuşii obţinuţi au fost testaţi ca inhibitori ai proliferării celulelor de leucemie umană HL-60. A fost stabilit că hidrazonele în baza 2-piridin aldehidei, aldehidei salicilice şi compuşii complecşi ai cuprului în baza 2-[2-(Piridin-2-ilmetilene)hidrazinil]-benzo [d]tiazolului şi 2-[2-(1-Piridin-2-il)etilidene)hidrazinil]benzo[d]tiazolului dihidrat sunt cei mai activi agenţi antiproliferativi obţinuţi în acest studiu. Unii din compuşi au fost testaţi ca inhibitori de proliferare a celulelor HepG2, MCF-7 şi LNCaP. Au fost calculate constantele de stabilitate a compuşilor complecși în baza 2-[2-(Piridin-2-ilmetilene)hidrazinil]-benzo[d] tiazolului şi 2-[2-(1-Piridin-2-il)etilidene)hidrazinil]benzo[d]tiazolului dihidrat.
  • Thumbnail Image
    Item
    THE USE OF qNMR SPECTROSCOPY FOR ANALYTICAL EVALUATION OF LAVENDER EXTRACTS. DETERMINATION OF ROSMARINIC ACID
    (CEP USM, 2022-09-29) Bîrcă, Natalia; Barba, Alic; Kulcițki, Veaceslav